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灰树花孔菌超微粉体内抗肿瘤作用研究 被引量:1

Anti-tumor activities of Grifola frondosa submicron powder on tumor- bearing mice
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摘要 通过研究肿瘤抑制率、脏器指数、肿瘤切片的观察以及血清中影响因子干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、血管内皮细胞生长因子(VEGF)、过氧化氢酶(CAT)、谷胱甘肽-过氧化物酶(GSH-PX)和超氧化物歧化酶(SOD)等指标的变化对比分析灰树花孔菌Grifola frondosa子实体粗粉及灰树花孔菌子实体超微粉对Hep-A-22荷瘤小鼠体内抗肿瘤和免疫调节作用。结果表明,各剂量组分均具有抑制肿瘤生长作用,其中灰树花孔菌超微粉高剂量组(1 500mg/kg)抑瘤效果最佳,与模型组比较有极显著性差异(P〈0.01)。通过HE染色后的肿瘤细胞可观察到坏死面积增大,同时该组血清中IFN-γ、IL-2、VEGF、GSH-PX和SOD含量显著增加(P〈0.01或P〈0.05),并与抑制肿瘤具有一定相关性。 Determination of tumor inhibition rate and spleen and thymus index, and observation of tumor slices and the changes of interferon-γ (IFN-γ), interleukin-2 (IL-2), vascular endothelial growth factor (VEGF), catalase (CAT), glutathione-peroxidase (GSH-PX) and superoxide dismutase (SOD) in serum were carried out to analyze the anti-tumor activities and immune regulation effects of Grifola frondosa fruiting body coarse powder and submicron powder on Hep-A-22 tumor-bearing mice. The results showed that the anti-tumor remedy of high dose submicron powder (1 500mg/kg) experimental group was of the best effect showing significant difference (P〈0.01) as compared with the model experimental group. Increased necrotic area of tumor was observed by HE staining. The content of IFN-γ, IL-2, VEGF, GSH-PX and SOD in serum of the treated group were significantly increased, showing a correlation with the tumor inhibition rate.
作者 刘佳 包海鹰 白日忠 图力古尔 LIU Jia1,2, BAO Hai-Ying1,2, BAI Ri-Zhong3, BAU Tolgor2(1.College of Traditional Medicine, Jilin Agricultural University, Changchun, Jilin 130118, China; 2.Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, China; 3.Gaosida Nano Material Equipment Co. Ltd., Siping, Jilin 136001, China)
出处 《菌物学报》 CSCD 北大核心 2018年第2期226-236,共11页
基金 长江学者和创新团队发展计划项目(IRT-15R25)
关键词 灰树花孔菌 超微粉 抗肿瘤 干扰素-Γ Grifolafrondosa, submicron powder, anti-tumor, interferon-γ (IFN-γ)
作者简介 Corresponding author. E-mail: baohaiying2008@126.com
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