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三维适形放疗同步吉西他滨联合多西他赛方案化疗治疗老年晚期膀胱癌的疗效观察 预览

Efficacy of three-dimensional conformal radiotherapy concurrent gemcitabine com- bined with docetaxel for advanced bladder cancer in the elderly
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摘要 目的 探讨三维适形放疗同步吉西他滨联合多西他赛(GT)方案化疗治疗老年晚期膀胱癌的疗效。方法将2015年1月至2016年6月新乡市中心医院收治的老年晚期膀胱癌患者96例,按照随机数字表法分为对照组与研究组,每组48例。对照组仅给予GT方案进行化疗,研究组在此基础上给予同步三维适形放疗,4周为1个疗程,均治疗2个疗程。对比两组临床疗效、治疗前后尿膀胱癌抗原(UBC)、透明质酸(HA)、核基质蛋白22(NMP22)水平、治疗期间不良反应发生情况及1、2年生存率。结果研究组治疗后总有效率为79.17%,高于对照组的58.33%(P〈0.05)。治疗后研究组UBC、HA、NMP22水平与对照组、治疗前相比较低(P〈0.05)。两组患者血小板降低、白细胞降低、恶心呕吐、脱发、肝功能损害、下尿路症状和肠道反应不良反应发生率对比差异无统计学意义(P〉0.05)。研究组1年生存率为70.83%,2年生存率为43.75%;对照组1年生存率为5833%,2年生存率为22.92%;研究组1年生存率、2年生存率均高于对照组(P〈0.05)。结论三维适形放疗联合GT化疗治疗老年晚期膀胱癌疗效较好,可以有效抑制肿瘤标志物水平,提高1、2年生存率,且未增加不良反应,适于临床推广。 ObjectiveTo evaluate the clinical efficacy of threedimensional conformal radiotherapy concurrent gemcitabine combined with docetaxel (GT) in the treatment of advanced bladder cancer in the elderly. Methods A total of 96 elderly patients with advanced bladder cancer treated during Jan. 2015 and June 2016 were randomly divided into two groups. The control group (n=48) received GT regimen chemotherapy,and the study group (n=48) received threedimensional conformal radiotherapy besides GT. After 8 weeks of treatment,the clinical efficacy,urinary bladder cancer antigen (UBC),hyaluronic acid (HA),nuclear matrix protein22 (NMP22),adverse reactions during treatment and 1 and 2year survival rates were compared between the two groups. Results The total effective rate was 79.17% in the study group and 58.33% in the control group,with significant difference between the two groups (P〈0.05). After treatment,the levels of UBC,HA and NMP22 in the study group were lower than those before treatment,and lower than those in the control group (P〈0.05). There were no significant differences between the two groups in the incidence of thrombocytopenia,white blood cell reduction,nausea,vomiting,hair loss,liver function impairment,lower urinary tract symptoms and intestinal reactions (P〉0.05). The 1year survival rate was 70.83% in study group and 58.33% in the control group,and the 2year survival rate was 43.75% in the study and 22.92% in the control group (P〈0.05). Conclusion Threedimensional conformal radiotherapy combined with GT regimen chemotherapy is effective in the treatment of advanced bladder cancer in the elderly. It can effectively inhibit tumor markers,improve the 1 and 2year survival rates,and cause no adverse reactions. It is suitable for clinical promotion.
作者 陈利军 马焱 CHEN Li-jun1 ,MA Yan2 (1. Department of Radiotherapy, Central Hospital of Xinxiang, Xinxiang 453000; 2. the First Department of Surgical Gynopathy,Tumor Hospital of Xinjiang Medical University,Urumehi 830000,China)
出处 《现代泌尿外科杂志》 CAS 2018年第2期123-127,共5页 Journal of MOdern Urology
关键词 三维适形放疗 吉西他滨 多西他赛 化疗 老年 晚期 膀胱癌 three dimensional conformal radiotherapy gemcitabine docetaxel chemotherapy elderly advanced bladder cancer
作者简介 陈利军(1969-),女(汉族),本科,副主任医师.研究方向:肿瘤放射治疗.E—mail:xyjhddr@sina.com
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