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胃癌肝转移的分子机制 被引量:1

Molecular Mechanisms of Gastric Cancer with Liver Metastasis
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摘要 胃癌肝转移是影响胃癌病人治疗和预后的主要因素之一,胃癌肝转移的早期诊断、治疗和预后均不容乐观。目前,关于胃癌肝转移的分子调控机制知之甚少。一般认为,胃癌细胞脱离原发灶,侵入血管到达肝脏定植的过程涉及诸多分子的变化及细胞间的相互作用。该文将对胃癌肝转移过程的前沿研究进展及其诊断治疗现状作一综述,以期更全面地了解胃癌肝转移的分子调控机制,为胃癌肝转移患者提供综合性的诊治理论依据。 Liver metastasis of gastric cancer is one of the main factors that affect the treatment and prognosis of patients with gastric cancer. Early diagnosis, treatment and prognosis of liver metastasis of gastric cancer are not optimistic. However, little is known about the molecular mechanisms of liver metastasis of gastric cancer. In general, the process of stomach cancer cells, migrated from the primary tumor and colonized in the liver tissue by invading vessels, is involved in many molecular signaling and cell-cell interactions. Herein, we review the research advances in the process of liver metastasis and the status quo of diagnosis and treatment of gastric cancer patients with liver metastasis. This review will help us to get a more comprehensive understanding of the molecular regulation mechanism of liver metastasis of gastric cancer and provide a diagnosis and treatment basis.
作者 饶显平 郭东阳 周天华 卓巍 Rao Xianping, Guo Dongyang, Zhou Tianhua, Zhuo Wei (Department of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China)
出处 《中国细胞生物学学报》 CAS CSCD 2018年第1期7-16,共10页 Chinese Journal of Cell Biology
基金 国家自然科学基金(批准号:91740205、1771540、31620103911) 中央高校基本科研业务费专项资金(批准号:2017QNA7005)资助的课题
关键词 胃癌 肝转移 分子机制 微环境 gastric cancer liver metastasis molecular mechanism microenvironment
作者简介 通讯作者。Tel:0751-88208258,E-mail:tzhu@zju.edu.cn;通讯作者。Tel:0751-88208257,E-mail:0012049@zju.edu.cn
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