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循环肿瘤DNA与结直肠癌的靶向治疗

Circulating tumor DNA and targeted therapy in colorectal cancer
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摘要 液体活检之循环肿瘤DNA是一种快速、经济、可靠的恶性肿瘤血液检测方法,因其无创性、便捷性、高度重复性等特点而具有广泛的应用前景。就结直肠癌靶向治疗而言,连续监测循环肿瘤DNA的水平变化及其特异性基因改变,有望实现结直肠癌的预后判断、耐药监测、疗效评估,甚至指导联合靶向治疗.更加精准地指导结直肠癌的治疗。 The detection of circulating tumor DNA is a quick, low cost and reliable approach of liquid biopsy of cancer. It has a wide range of applications for tumor screening because of its noninvasive, convenient and highly repeatable features. In terms of the targeted therapy in patients with colorectal cancer, serial monitoring of circulating tumor DNA, especially for the specific genetic alterations, can be used for prognosis, monitoring resistance, evaluation of therapeutic effects and screening combined targeted therapy. Therefore, it will guide more precise treatment of eolorectal cancer.
作者 黄玉庭 徐建明 Huang Yuting, Xu Jianming (Department of Gastrointestinal Oncology, the Affiliated Hospital Cancer Center, Military Academy of Medical Sciences, Belting 100071, China)
出处 《中华肿瘤杂志》 CSCD 北大核心 2018年第3期161-165,共5页 Chinese Journal of Oncology
关键词 循环肿瘤DNA 结直肠肿瘤 靶向治疗 液体活检 Circulating tumor DNA Colorectal neoplasms Targeted therapy Liquid biopsy
作者简介 通信作者:徐建明,Email:jmxu2003@yahoo.com
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