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治未病理念在肥胖高血压患者早期肾损害中的应用 预览

Clinical Observation on Effects of Traditional Chinese Medical Preventive Treatment on Early Renal Damage of Obese and Hypertensive Patients
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摘要 目的:观察活血潜阳方辅以耳穴及恬淡疏息法对肥胖高血压患者早期肾损害的干预作用。方法:将60例伴早期肾损害的肥胖高血压患者随机分为对照组及治疗组,每组30例。2组患者在原治疗方案的基础上均进行健康宣教,治疗组则予活血潜阳方辅以耳穴及恬淡疏息法干预3个月。干预前后采集患者一般资料、诊室血压、动态血压,中医证候积分、糖脂代谢、早期肾损害等指标进行比较。结果:治疗组患者体重、腰围、BMI均较治疗前显著下降(P〈0.05);治疗组收缩压及舒张压均较治疗前显著下降(P〈0.05),治疗组降压有效率70.0%显著优于对照组(P〈0.01);18例对照组患者及17例治疗组患者完成了动态血压监测,治疗组24 h平均收缩压(24 h SBP)及夜间平均收缩压(n SBP)均较治疗前显著下降(P〈0.05);治疗组中总胆固醇(TC)、甘油三酯(TG)、空腹胰岛素(FIN)、HOMA-IR均较治疗前显著下降(P〈0.05);治疗组尿MA/尿肌酐较治疗前显著下降(P〈0.05);治疗组中医证候积分较前显著下降(P〈0.01),治疗有效率为76.7%优于对照组(P〈0.05)。以上结果对照组治疗前后无显著变化(P〉0.05)。结论:活血潜阳方辅以耳穴及恬淡疏息法治疗3个月可显著改善肥胖高血压患者早期肾损害。 Objective: To observe the effects of traditional Chinese medical preventive treatment on the early renal damage of obese and hypertensive patients. Methods: A total of 60 patients with obesity and essential hypertension were randomly divided into two groups, 30 patients each. Health education was carried out for all the patients. The treatment group was treated with Huoxue Qianyang Qutan recipe, auricular point therapy, Tiandan Shuxi exercises. General information, traditional Chinese medicine symptoms, glu- cose and lipid metabolism indicators, ambulatory blood pressure and urine creatinine and micro-albumin were observed and compared before and after treatment. Results: The weight, waist and BMI of the treatment group patients were significantly decreased after the therapy ( P 〈 0.05 ) . The systolic pressure and diastolic pressure were decreased in both groups ( P 〈 O. 05 ) . The effective rate in treatment group was 70. 0%. After treatment, the 24 h SBP and nSBP were significantly decreased in treatment group ( P 〈 0. 05 ). After treatment, TC, LDL-C, FIN, HOMA-IR were significantly decreased in treatment group ( P 〈 0. 05 ) . After treatment, urine MA/CR were significantly decreased in treatment group ( P 〈 0. 05 ) . After treatment, the TCM scores were significantly decreased in both groups (P 〈 0.05 ) . The effective rate in treatment group was 76. 7%, which was significantly higher than that in control group ( P 〈 0.05) . Conclusion: After three months treatment, the therapy can improve the early renal damage of obese and hypertensive patients.
作者 周训杰 桂明泰 姚磊 芦波 李建华 韩亚楠 符德玉 Zhou Xunjie, Gui Mingtai, Yao Lei, Lu Bo, Li Jianhua, Han Yanan, Fu Deyu( Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200437, China)
出处 《成都中医药大学学报》 2018年第2期41-44,共4页 Journal of Chengdu University of Traditional Chinese Medicine
基金 上海市“治未病”预防保健项目体系建设项目政策和技术类子项目(ZY3-FWMS-1-1001-KYJS-11) 上海市进一步加快中医药事业发展三年行动计划(ZY3-CCCX-3-3026) 上海中医药大学预算内项目(2015YSN4)
关键词 原发性高血压 中心性肥胖 早期肾损害 治未病 Essential hypertension Central obesity Early renal damage Preventive treatment of disease
作者简介 第一作者:周训杰,男,1980年生;医学博士,主治医师;E-mail:kensin2000@163.com。;通信作者:符德玉,女,1965年生;医学博士,教授;Email:rdy65@126.com。
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