Objective To investigate the diagnostic value of serum LAP, ALT combined with γ-GT in hyperthyroidism complicated with liver injury. Methods 188 patients with hyperthyroidism admitted to our hospital from October 2015 to November 2017 were selected. According to the results of the examination, they were divided into hyperthyroid liver damage group （n = 98 ） and hyperthyroid non-liver damage group （n = 90）. 100 healthy subjects were selected as control group at the same period. The levels of serum FT3 ,FT4, TSH, LAP, ALT, and γ-GT in each group were compared, and the correlation analysis and diagnostic indexes were performed. Results The levels of serum FT3 , FT4 in hyperthyroid liver damage group and non-liver damage group were significantly higher than those in control group, but TSH was lower than that in control group （ P 〈 0.05 ）. The levels of serum PT3, PT4 in hyperthyroid liver damage group were significantly higher than those in nonliver damage group （ P 〈 0.05 ）, but TSH between two groups had no difference （ P 〉 0.05 ）. The levels of serum LAP, ALT, and γ- GT in hyperthyroid liver damage group and hyperthyroid non- liver damage group were significantly higher than those in control group, and the levels of serum LAP, ALT,γ-GT in hyperthyroid liver damage group were significantly higher than those in non-hyperthyroid damage lesion group （ P 〈 0.05 ）. After Spearson correlation analysis, FT3 and FT4 were positively correlated with liver function indicators （ LAP, ALT, γ- GT ）. The sensitivity （ 90 % ）, specificity （ 95.8 % ） and accuracy （ 92.9 % ） of the combined detection of three indicators were significantly higher than those of any single index （ P 〈 0.05 ）. Conclusion Abnormally elevated levels of LAP, ALT, and ,γ- GT in patients with hyperthyroidism liver injury are closely related to thyroid hormones, and the combined detection is beneficial to the early diagnosis of hyperthyroidism liver injury.
Labeled Immunoassays and Clinical Medicine