期刊文献+

中国5个县儿童乙型病毒性肝炎疫苗接种和血清学调查

Vaccination coverage and seroprevalence of hepatitis B among children in five counties of China
分享 导出
摘要 目的了解乙型病毒性肝炎(乙肝)疫苗(Hepatitis B vaccine,HepB)纳入国家免疫规划前后HepB接种率、乙肝血清流行率。方法从4个省份选取5个县(市、区),随机抽取2001年、2005年、2009年出生儿童,调查HepB免疫史并检测乙肝病毒表面抗体(Hepatitis B surface antibody,Anti-HBs)、乙肝病毒表面抗原(Hepatitis B surface antigen,HBsAg)、乙肝病毒核心抗体(Hepatitis B core antibody,Anti-HBc),进行比较分析。结果 2001年、2005年、2009年出生儿童3剂全程HepB(HepB_(1-3))接种率分别为96.80%(121/125)、100%(157/157)、100%(160/160)(Fisher精确概率法,P=0.01),首剂及时(HepB_(1t))接种率分别为75.20%(94/125)、84.71%(133/157)、90.63%(145/160)(χ~2=12.58,P=0.002),Anti-HBs阳性率分别为68.15%(107/157)、70.97%(110/155)、72.90%(113/155)(χ~2=0.86,P=0.65),HBsAg阳性率分别为4.00%(6/150)、1.32%(2/152)、2.50%(3/120)(Fisher精确概率法,P=0.38),Anti-HBc阳性率分别为3.90%(6/154)、1.92%(3/156)、0.64%(1/156)(Fisher精确概率法,P=0.11)。城镇和农村地区HBsAg阳性率分别为0.53%(1/190)、4.31%(10/232)(Fisher精确概率法,P=0.01),本地和流动人口分别为1.63%(5/307)、5.22%(6/115)(Fisher精确概率法,P=0.08)。结论 HepB纳入免疫规划后HepB_(1-3)接种率维持较高水平、HepB_(1t)接种率大幅提高,有效控制了乙肝感染,需加强农村地区、流动人口的乙肝防控工作。 Objective To assess the vaccination coverage and seroprevalence of hepatitis B among children before and after hepatitis B vaccine( HepB) was introduced into China's Expanded Program on Immunization( EPI). Methods We selected random samples of children born in 2001,2005 and 2009 from five counties of four provinces and determined HepB vaccination history and measured hepatitis B surface antibody( Anti-HBs),hepatitis B surface antigen( HBsAg),and hepatitis B core antibody( Anti-HBc) levels. We conducted a comparative analysis of the 3 birth-year samples. Results Among children born in 2001,2005,and 2009,coverage with 3 doses of HepB( HepB_(1-3)) were 96. 80%( 121/125),100%( 157/157),and 100%( 160/160)( Fisher's exact test,P = 0. 01),respectively; coverage rates for a timely first dose of HepB( HepB_(1t)) were 75. 20%( 94/125),84. 71%( 133/157),and 90. 63%( 145/160)( χ~2= 12. 58,P = 0. 002); Anti-HBs positivity rates were 68. 15%( 107/157),70. 97%( 110/155),and 72. 90%( 113/155)( χ~2= 0. 86,P = 0. 65); HBsAg positivity rates were 4. 00%( 6/150),1. 32%( 2/152),and 2. 50%( 3/120)( Fisher's exact test,P = 0. 38); Anti-HBc positivity rates were 3. 90%( 6/154),1. 92%( 3/156),and 0. 64%( 1/156)( Fisher's exact test,P = 0. 11). HBsAg positivity rates were 0. 53 %( 1/190) in urban areas and 4. 31%( 10/232) in rural areas( Fisher 's exact test,P = 0. 01),and were 1. 63%( 5/307) among local-born children and 5. 22%( 6/115) among migrant children( Fisher 's exact test,P = 0. 08). Conclusions HepB_(1-3) coverage was very high in all three years; HepB1 tcoverage increased significantly by time; and hepatitis B infection was controlled effectively after introduction of HepB into China 's EPI system. We should enhance hepatitis B control and prevention in rural areas and among migrant populations.
作者 岳晨妍 李迪 李燕 郑徽 郑慧贞 黄卓英 马福宝 李慧 王亚敏 安志杰 王华庆 Yue Chenyan1, Li Di2, Li Yan1 , Zheng Hui1 , Zheng Huizhen3, Huang Zhuoying4, Ma Fubao5, Li Hui6, Wang Yamin1 , An Zhijie1 , Wang Huaqing1 ( (1. Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China; 2. Harbin Medical University, Harbin 150086, Heilon~iang, China ; 3. Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, G uangdong, China; 4. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; 5. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, Jiangsu, China; 6. Gansu Provincial Center for Disease Control and Prevention, Lanzhou 730000, Gansu, China)
出处 《中国疫苗和免疫》 北大核心 2018年第3期274-279,共6页 Chinese Journal of Vaccines and Immunization
基金 “十二五”国家科技重大专项(2012ZX10004703)
关键词 乙型病毒性肝炎 血清流行率 乙型肝炎疫苗 接种率 Hepatitis B Seroprevalence Hepatitis B vaccine Coverage
作者简介 通信作者:王华庆,Email:wanghq@chinacdc.cn.
  • 相关文献

参考文献3

二级参考文献24

  • 1卓家同,钟革,蓝光华,刘巍,郑志刚,杨庆利.不安全注射与乙型肝炎病毒传播的流行病学回顾性实验研究[J].中国计划免疫,2006,12(2):140-142. 被引量:8
  • 2Liang XF, Bi SL, Yang Z, et al. Evaluation of the Impact of Hepatitis B Vaccination among Children Born during 1992-2005 in China[J]. Journal of Infectious Diseases, 2009, 200 ( 1 ) :39-47. 被引量:1
  • 3Meheus A. Risk of hepatitis B in adolescence and young adulthood [J]. Vaccine, 1995, 13 (Suppl 1 ) :31-34. 被引量:1
  • 4Kurcer MA, Pehlvan EP. Hepatitis B seroprevalance and risk factors in urban areas of Malatya[J]. Turk J Gastroenterol,2002, 13 (1): 1-5. 被引量:1
  • 5Cui FQ, Wang XJ, Cao L, et al. Progress in Hepatitis B PreventionThrough Universal Infant Vaccination - China, 1997-2006 [ J ]. MMWR, 2007,56 ( 18 ) :441-445. 被引量:1
  • 6卫生部疾病预防控制局,中国疾病预防控制中心.全国人群乙型病毒性肝炎血清流行病学调査报告[M].北京:人民卫生出版社,2011:1-57. 被引量:3
  • 7张红杰.烟台市新生儿乙肝疫苗效果评价及低/无应答者再免疫效果分析[D].济南:山东大学,2012. 被引量:3
  • 8Tong CY, Robson C,Wu Y,et al. Post - vaccination serological test re-sults of infants at risk of perinatal transmission of hepatitis B using anintensified follow - up program in a London centre[j]. Vaccine, 2013,31(31):3174-3178. 被引量:1
  • 9Cui F,Luo H,War屯 F,et al. Evaluation of policies and practices to pre-vent mother to child transmission of hepatitis B virus in China: resultsfrom China GAVI project final evaluation[J]. Vaccine,2013,31 (S9):J36-42. 被引量:1
  • 10Greenup AJ, Tan PK, Nguyen V,et al. Efficacy and safety of tenofovirdisoproxil fumarate in pregnancy to prevent perinatal transiriission ofhepatitis B virus[J]. J Hepatol,2014,61(3) :502 - 507. 被引量:1

共引文献26

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈