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血栓弹力图与常规凝血四项评价临床患者凝血功能的对比研究 预览

Comparison Study on Thrombelastogram and Four Routine Coagulation Indexes in Evaluating the Clinical Patients
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摘要 目的分别采用血栓弹力图与常规凝血四项评价临床患者凝血功能,并对其结果一致性进行对比。方法选取2016年3月—2017年3月在该院接受诊治的380例患者作为该次研究的主要对象,首先对所有患者进行凝血酶原时间、纤维蛋白、活化部分凝血活酶时间以及血小板含量等四项常规凝血检查,然后再对所有患者进行血栓弹力图检查,通过两种检查方法对患者的凝血功能进行评价,并对两种检查方法的临床价值进行对比分析。结果 TEG检查中的血栓最大震幅(59.49±5.18)min与活化部分凝血活酶时间(56.10±9.49)s、纤维蛋白原(3.65±0.77)g/L以及血小板(191.02±37.89)×109/L之间差异有统计学意义(P=0.028,0.000,0.000),而与凝血酶原时间(14.55±3.15)s之间差异无统计学意义(P=0.165);TEG检查中的凝血反应时间(8.28±2.21)min与APTT、PT以及Fib之间差异有统计学意义(P=0.001,0.000,0.043),而与Plt之间差异无统计学意义(P=0.075);TEG检查中的血块形成时间(2.73±0.55)min与Fib和Plt之间差异有统计学意义(P=0.000,0.000),而与APTT和PT之间差异无统计学意义(P=0.417,0.235);TEG检查中的血凝速率(Angle)与APTT、PT、Fib及Plt之间均差异有统计学意义(P=0.000,0.000,0.001,0.000)。结论血栓弹力图检查与常规凝血四项检查的结果具有相关性,但其一致性不高,检查灵敏度较低,且两者不能互相代替,在临床上进行结合使用,能够大幅度提高检查结果的准确率。 Objective To respectively use the thrombelastogram and four routine coagulation indexes to evaluate the clinical patients and compare the consistency of results. Methods 380 cases of patients diagnosed in our hospital from March 2016 to March 2017 were selected as the research objects, and the four routine coagulation indexes such as prothrombin time, fibrin, activated partial thromboplastin time and platelet content of all patients were examined, and then all patients were examined by the thrombelastogram, and the coagulation effect of patients of the two groups was evaluated, and the clinical value of the two groups was evaluated and analyzed. Results The differences in the maximum amplitude of thrombus, activated partial thromboplastin time, fibrinogen, and platelet in the TEG examination were statistically significant, which were respectively(59.49±5.18)min,(56.10±9.49)s,(3.65±0.77)g/L,(191.02±37.89) ×109/L,(P =0.028,0.000,0.000), but the difference in the prothrombin time was not statistically significant, which was(14.55±3.15)s,(P=0.165), and the differences in the coagulation cascade time(8.28±2.21)min, APTT, PT, Fib in the TEG examination was statistically significant(P=0.001,0.000,0.043), but the difference in the Plt was not statistically significant(P=0.075),and the differences in the clotting time(2.73±0.55)min, Fib and Plt in the TEG examination were statistically significant(P=0.000,0.000), but the differences in the APTT and PT were not statistically significant(P=0.417,0.235), and the differences in the Angle, APTT, PT, Fib, Plt in the TEG examination between the two groups were statistically significant(P=0.000,0.000,0.001,0.000). Conclusion The thrombelastogram is correlated with the four routine coagulation indexes,but the consistency is not high and the examination sensitivity is lower, and the two can not replace each other, and we should combine the two in clinic thus greatly improving the accurate rate of examination results.
作者 桂木梅 刘欣 GUI Mu-mei, LIU Xin (Department of Blood Transfusion, Changshou District People's Hospital, Chongqing, 401220 China)
出处 《系统医学》 2018年第5期20-22,共3页
关键词 血栓弹力图 常规凝血四项 临床患者 凝血功能 评价效果 Thrombelastogram Four routine coagulation indexes Clinical patients Coagulation function Evaluationeffect
作者简介 桂木梅(1980一),女,重庆人,本科,主管技师,研究方向:输血方面。;[通讯作者]刘欣(1983一),女,重庆人,本科,主管检验师,研究方向:输血方面,E-mail:27023282@qq.com.
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