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脑心通胶囊治疗冠心病合并高脂血症的系统评价 预览 被引量:2

Systematic review on Naoxintong Capsule in treatment of coronary heart disease complicated by hyperlipidemia
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摘要 目的系统评价脑心通胶囊治疗冠状动脉粥样硬化性心脏病(冠心病)合并高脂血症的疗效和安全性;方法计算机检索Cochrane图书馆、Pub Med、EMbase、CNKI、CBM、VIP、万方数据库,纳入相关RCT,并进行评价,采用Revman5.3软件分析数据;结果纳入19篇RCTs,共1683例受试者。相比对照组,步长脑心通的血脂总疗效较高(RR=1.16,95%CI:1.06-1.26,P〈0.0007)。治疗后总胆固醇(TC)水平低于对照组(WMD=-1.03,95%CI:-1.18--0.88,P〈0.001)。治疗后三酰甘油(TG)水平低于对照组(WMD=-0.63,95%CI:-0.74--0.53,P〈0.001);治疗后高密度脂蛋白胆固醇(HDL-C)高于对照组(WMD=0.20,95%CI:0.15-0.28,P〈0.001);治疗后低密度脂蛋白胆固醇(LDL-C)水平低于对照组(WMD=-0.66,95%CI:-0.79--0.53,P〈0.001);各组不良反应发生率差异均无统计学意义(RR=3.52,95%CI:1.00-12.38,P=0.05)。结论脑心通治疗冠心病合并高脂血症疗效明显,对TC、TG、HDL-C、LDL-C的改善有效,不良反应发生率未见与其他药物有明显差异,推荐临床应用于冠心病合并高脂血症的治疗,并建议补充更多高质量的相关研究。 Objective To review systematically curative effect and safety of Buchang Naoxintong Capsule in treatment of coronary heart disease(CHD) complicated by hyperlipidemia. Methods The databases of Cochrane Library, Pub Med, EMbase, CNKI, CBM, VIP and Wan Fang Data were retrieved with computer for searching related randomized controlled trials(RCT), and then given the included RCT were reviewed and analyzed by using Revman5.3 software. Results There were totally 19 RCT included involved 1683 patients. Compared with control group, the total curative effect on blood fat was higher(RR=1.16, 95%CI: 1.06-1.26, P0.0007), level of total cholesterol(TC) was lower(WMD=-1.03, 95%CI:-1.18--0.88, P0.001), level of triglyceride(TG) was lower(WMD=-0.63, 95%CI:-0.74--0.53, P0.001), level of high-density lipoprotein-cholesterol(HDL-C) was higher(WMD=0.20, 95%CI: 0.15-0.28, P0.001), and low-density lipoprotein-cholesterol(LDL-C) was lower(WMD=-0.66, 95%CI:-0.79--0.53, P0.001) in test group. The difference in adverse reaction incidence had no statistical significance between 2 groups. Conclusion Buchang Naoxintong Capsule has significant curative effect in treatment of CHD complicated by hyperlipidemia, and can effectively improve levels of TC, TG, HDL-C and LDL-C. There is no significant difference in adverse reactions compared with other drugs. Buchang Naoxintong Capsule is recommended for CHD complicated by hyperlipidemia, and more related studies with higher quality are needed to supplement the conclusion.
作者 师帅 褚瑜光 宋庆桥 杜柏 邱志凌 胡元会 纪鑫毓 Shi Shuai, Chu Yuguang, Song Qingqiao, Du Bai, Qiu Zhiling, Hu Yuanhui, Ji Xinyu. (Guangan'men Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.)
出处 《中国循证心血管医学杂志》 2018年第5期533-537,共5页
关键词 脑心通胶囊 冠心病 高脂血症 系统评价 Naoxintong Capsule Coronary heart disease Hyperlipidemia Systematic review
作者简介 通讯作者:师帅,E—mail:shawshaw@126.com
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