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从大鼠长毒实验评价异型南五味子提取物药理安全性

Study on Pharmacological Long Toxicity Safety of Extracts of Kadsura Heteroclita on Rats
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摘要 目的:从大鼠长毒性实验研究评价异型南五味子提取物的药理毒理学安全性指数。方法:实验大鼠随机分为高、中、低3个药物剂量组和空白对照组,药物剂量组按不同浓度异形南五味子提取物有效成分总三萜溶液给药,连续给药3个月后,检测动物基本情况、血常规、肝肾功能、血糖血脂、凝血指标、各脏器组织指数和病理学组织检查,并观察停药后1.5个月各指标的恢复情况。结果:在给药的中期和末期,中、低药物剂量组未发现可致实验大鼠毒性症状和各项指标异常,高剂量药物组发现肝脏、肾上腺质量有轻度增加,病理切片示肝脏细胞颗粒增粗,但以上指标在撤药后恢复期复查均正常,与空白对照组比较,差异无统计学意义(P〉0.05)。结论:异型南五味子提取物总三萜对实验动物长毒性实验研究,在治疗剂量范围内用药安全,有进一步深入开发前景。 Objective To evaluate the pharmacological toxicological safety index of heterotypic Schisandra Schisandra extract from the experimental study of long toxicity in rats. Method The test rats were randomly divided into three drug dose groups: high, medium and low, and a blank control group. The drug dose group was administered according to the total concentration of the three components of the active ingredient of Kadsura heteroclita extract. After 3 months of continuous administration, the basic conditions of the animals, blood routine, liver and kidney function, blood sugar and blood lipids, blood coagulation index, organ index and pathological examination were examined, and the recovery of each index one and a half months after stopping the drug was observed. Result In the middle and late stages of administration,no toxic symptoms and various indicators of experimental rats were found in the middle and low drug dose groups.The high-dose drug groups found a slight increase in liver and adrenal weight,and pathological slices showed that liver cell particles were thickened. However, the above indexes were normal during the recovery period after withdrawal, and there was no significant difference compared with the blank control group. Conclusion The longtoxicity test of the total Kadsura heteroclita extract on the test animals, the safety of the drug within the therapeutic dose range, has further prospects for further development.
作者 邓鸣 DENG Ming (Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine, Guangdong Shenzhen 518034)
出处 《深圳中西医结合杂志》 2018年第11期46-49,共4页 Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金 广东省2014年科学技术厅项目资助课题(2014A020220178)
关键词 异形南五味子提取物 总三萜 长毒性实验 动物实验 大鼠 Extract of special-shaped kadsura heteroclita Total triterpenes Long toxicity test Animal experiment Rat
作者简介 邓鸣,女,副主任医师,主要研究方向是中西结合风湿病学。
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