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肾康注射液治疗心肾综合征的疗效观察 预览

The effect of Shenkang injection in treatment of Cardiorenal syndromes( CRS)
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摘要 目的:探讨肾康注射液治疗心肾综合征的疗效及安全性。方法:选取2016年7月-2017年8月就诊的心肾综合征患者90例,随机分为治疗组与对照组各45例。对照组采用西医常规治疗,治疗组在对照组治疗基础上联用肾康注射液,疗程8周,比较两组临床疗效及安全性。结果:治疗8周后,(1)治疗组血清肌酐(Scr)、尿素氮(BUN)、24 h尿蛋白、NT-proBNP、胱抑素C(CysC)、尿微量白蛋白排泄(UAER)、左心室收缩末期内径(LVEDD)、左心室舒张末期内径(LVEED)水平较对照组下降,差异有统计学意义(P〈0.05),Ccr、左心室射血分数(LVEF%)较对照组升高,差异有统计学意义(P〈0.05);(2)治疗组临床总有效率82.22%,明显高于对照组临床总有效率48.89%(P〈0.05);(3)两组在不良反应方面差异无统计学意义(P〉0.05)。结论:肾康注射液可有效改善心肾综合征患者心、肾功能,具有临床指导治疗意义。 Objective To assess the curative effect and security of Shenkang injection in treatment of Cardiorenal syndromes( CRS). Method 90 patients with CRS who had been diagnosed in July 2016-August 2017 were selected randomly divided into treatment group and control group( 45 cases in each group). The control group receive routine treatment,The treatment group was added with Shenkang treatment on the basis of the control group for 8 weeks. Clinical efficacy and security of the two group were compared. Results After 8 weeks of treatment.(1)compared with the control group,Scr、BUN、24 h urine protein、Cys C、UAER、NT-proBNP、LVESD、LVEDD in the treatment group were decreased significantly( P〈0. 05),Ccr、GFR、LVEF% in the treatment group were increased significantly( P〈0. 05).(2)The total effective rate of the treatment group was 82. 22%,significantly higher than that of the control group( 48. 89%)( P〈0. 05);(3)There was no significant difference in adverse reactions between the two group( P〈0. 05). Conclusion The heart and renal function in patients with CRS can be improved effectively.
作者 余文城 杨利颜 魏职皆 YU Wen - cheng1 , YANG Li - yah2, WEI Zhi - jie2 ( 1. Gaoyao Hospital of traditional Chinese Medicine, Zhaoqing 526000, China ; 2. Jindu Town Health Hospital, Zhaoqing 526000, China)
出处 《吉林医学》 CAS 2018年第7期1249-1252,共4页 Jilin Medical Journal
关键词 肾康注射液 心肾综合征 临床疗效 Shenkang injection Cardiorenal syndromes Clinical efficacy
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