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血清中性粒细胞、血小板/淋巴细胞比值与GIST患者的预后关系及临床意义 预览

Relationship between blood neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and prognosis of patients with gastrointestinal stromal tumor and its clinical significance
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摘要 目的探讨术前中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)与胃肠间质瘤(GIST)预后的相关性。方法回顾性分析2009年1月至2012年1月经病理确诊为GIST的64例患者的临床资料,分析术前NLR、PLR与GIST患者临床病理特征及预后的关系。结果 ROC曲线分析显示,NLR=2. 78,PLR=131. 85作为评价的分界点,高NLR组、高PLR组GIST患者的5年无复发率和5年生存率显著低于低NLR组、低PLR组,差异有统计学意义(P 〈0. 05)。NLR、PLR与GIST患者临床病理特征中细胞核分裂像和肿瘤大小有关。Cox多因素分析显示,NLR、PLR、核分裂像是GIST患者5年无复发率的独立危险因素(P 〈0. 05)。结论 NLR、PLR及核分裂像是影响GIST患者预后的危险因素。 Objective To investigate the relationship of preoperative blood neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) and prognosis of patients with gastrointestinal stromal tumor(GIST). Methods The clinical data of 64 patients with GIST in our hospitalfrom January 2009 to January 2012 were analyzed respectively,the relation between the NLR,PLR and the prognosis of patients with GIST was understood by the survival analysis. Results ROC curve analysis showed that NLR = 2. 78,PLR = 131. 85 were optimal cut-off values. The 5-year relapse free survival rate(RFS) of the patients with high NLR,high PLR were shorter than those of the low NLR,low PLR,the difference was significant(P 〈 0. 05). The 5-year overall survival rate(OS) of the patients with high NLR,high PLR were shorter than those of the low NLR,low PLR,the difference was significant(P 〈 0. 05). The NLR and PLR was related to mitotic figures and tumor size(P 〈 0. 05). NLR,PLR,mitotic figures were independent prognostic indicators of 5-year RFS in Cox multivariate analysis(P 〈 0. 05). Conclusion Blood NLR,PLR and mitotic figures have some predictive value for the prognosis of patients with GIST.
作者 汪泓 周徽 柯瑞盛 张坤 WANG Hong 1, ZHOU Hui 2,KE Rui-sheng 3,4 ,ZHANG Kun 4(1.Department of General Surgery,the 184th Hospital of PLA,Yingtan Jiangxi 335000,China;2.Department of General Surgery,Third Hospital of Wuhan City,Wuhan Hubei 400360,China;3.Clinical Medical School of Fuzhou General Hospital,Fujian Medical University,Fuzhou Fujian 350025,China;4.Department of Hepatobiliary Surgery,Fuzhou General Hospital of PLA,Fuzhou Fujian 350025,China)
出处 《局解手术学杂志》 2018年第11期801-805,共5页 Journal of Regional Anatomy and Operative Surgery
基金 福建省自然科学基金重点项目(2015J01406)
关键词 中性粒细胞 淋巴细胞 血小板 胃肠间质瘤 血清 neutrophile granulocyte lymphocyte platelet gastrointestinal stromal tumor serum
作者简介 [通信作者]张坤,E-mail:zhangkun73@aliyun.com
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