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西那卡塞联合小剂量骨化三醇对维持性血液透析患者FGF–23及血管钙化的影响 预览 被引量:2

Effect of Cinacalcet combined with low-dose Calcitriol on FGF-23 and vascular calcification for patients under maintenance hemodialysis
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摘要 目的:探究西那卡塞联合小剂量骨化三醇对维持性血液透析患者成纤维细胞生长因子-23(FGF-23)及血管钙化的影响。方法:选取40例行维持性血液透析的患者作为研究对象,随机分为对照组与观察组,每组20例,对照组患者给予西那卡塞治疗,观察组患者给予西那卡塞联合小剂量骨化三醇治疗,应用ELLSA法检测40例患者的FGF-23水平,应用腰椎侧位X片对患者腹主动脉钙化现象进行检查。结果:观察组患者的FGF-23水平降低优于对照组患者(P<0.05),与对照组相比,观察组患者的血管钙化现象明显缓解(P<0.05)。结论:西那卡塞联合小剂量骨化三醇对维持性血液透析患者FGF–23及血管钙化的影响效果显著,值得临床推广应用。 Objective:To explore the effect of Cinacalcet combined with low-dose Calcitriol on fibroblast growth factor-23(FGF-23)and vascular calcification for patients under maintenance hemodialysis.Methods:40 patients undergoing maintenance hemodialysis were randomly divided into a control group and an observation group,with 20 cases in each group.Patients in the control group were given Cinacalcet for treatment,whereas those in the observation group were given Cinacalcet combined with low-dose of Calcitriol for treatment.ELLSA was applied to detect the level of FGF-23,and lateral lumbar X-ray examination was carried out to check the patients'abdominal aortic calcification.Results:The decrease of FGF-23 in the observation group was greater than that in the control group(P<0.05).Compared with the control group,the vascular calcification in the observation group was significantly relieved(P<0.05).Conclusion:The effect of Cinacalcet combined with low-dose Calcitriol is of significant effect on FGF-23 and vascular calcification in patients under maintenance hemodialysis,and therefore,it is of significant value to be popularized in clinical application.
出处 《包头医学院学报》 CAS 2018年第4期62-64,共3页 Journal of Baotou Medical College
关键词 西那卡塞 骨化三醇 维持性血液透析 成纤维细胞生长因子-23 血管钙化 Cinacalcet Calcitriol Maintenance Hemodialysis Fibroblast Growth Factor-23 Vascular Calcification
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