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血清中炎性因子在急性脑梗死患者中的临床价值分析 预览 被引量:1

Clinical value of serum inflammatory factor in patients with acute cerebral infarction
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摘要 目的 探讨血清中炎性因子检验结果对于急性脑梗死患者临床诊疗的参考价值。方法 选取河南省直机关第二医院2015 09—2016 04收治的74例急性脑梗死患者和同期接受体检的70例健康者为研究对象,分别作为观察组和对照组,经血清胱抑素C及凝血功能检验,对比2组受检者临床检验结果的差异,观察急性脑梗死患者治疗前后的临床检验结果变化。结果 与对照组相比,观察组患者的血清胱抑素C(CysC)水平[(1.51±0.39)mg/L>(1.08±0.18)mg/L]、血浆纤维蛋白(Fg)水平[(3.12±1.16)g/L>(2.57±1.12)g/L]以及低密度脂蛋白(LDL)水平[(2.28±0.58)mmol/L>(1.76±0.42)mmol/L]相对更高(P<0.05),而抗凝血酶Ⅲ(ATⅢ)水平[(68.12±16.38)μg/L<(82.91±17.64)μg/L]相对更低(P<0.05),血浆凝血酶原(PT)时间[(15.18±3.91)s<(21.78±5.92)s]、同型半胱氨酸(HCY)水平[(9.91±2.21)μmol/L<(18.85±4.25)μmol/L]相对更低(P<0.05)。与治疗前相比,治疗后急性脑梗死患者的CysC、Fg水平显著降低(P<0.05),而PT和ATⅢ显著升高(P<0.05)。结论 血清中炎性因子检验对于急性脑梗死患者的临床诊疗和预后判断有着重要的参考价值。 Objective To explore the reference value of serum inflammatory factor test results in clinical diagnosis and treatment of patients with acute cerebral infarction.Methods Seventy four patients with acute cerebral infarction admitted to our hospital September 2015 to April 2016 and Seventy healthy subjects who underwent physical examination at the same time were selected as the observation group and the control group.The serum cystatin C and coagulation function tests were performed.The differences of clinical test results between the two groups of subjects were compared,and the changes of clinical test results before and after treatment of patients with acute cerebral infarction were observed.Results Compared with the control group,the serum cystatin C(CysC)level in the observation group[(1.51±0.39)mg/L>(1.08±0.18)mg/L],plasma fibrin(Fg)level[(3.12±)1.16)g/L>(2.57±1.12)g/L]and low density lipoprotein(LDL)levels[(2.28±0.58)mmol/L>(1.76±0.42)mmol/L]were relatively higher(P<0.05).while antithrombinⅢ(ATⅢ)levels[(68.12±16.38)μg/L<(82.91±17.64)μg/L]relatively lower(P<0.05),plasma prothrombin(PT)time[(15.18±3.91)s<(21.78±5.92)s],homocysteine(HCY)level[(9.91±2.21)μmol/L<(18.85±4.25)μmol/L]is relatively lower(P<0.05).Compared with before treatment,the levels of CysC and Fg in patients with acute cerebral infarction were significantly lower(P<0.05),while those in PT and AT III were significantly increased(P<0.05).Conclusion Serum inflammatory factor test has important reference value for clinical diagnosis and prognosis of patients with acute cerebral infarction.
作者 蔚春生 耿超群 吴干斌 WEI Chunsheng[1];GENG Chaoqun[1];WU Ganbin[2]([1]Department of Clinical Laboratory,Second Provincial Hospital of Henan Province,Zhengzhou 450000,China;[2]the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450014,China)
出处 《中国实用神经疾病杂志》 2018年第13期1475-1479,共5页 Chinese Journal of Practical Neruous Diseases
基金 河南省教育厅科研重点项目(编号:14A350014)。
关键词 急性脑梗死 血清胱抑素 同型半胱氨酸 低密度脂蛋白 预后价值 Acute cerebral infarction Serum cystatin Homocysteine Low density lipoprotein Prognostic value
作者简介 蔚春生,Email:13027626988@163.com。
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