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超敏C反应蛋白、降钙素原及白细胞介素-10三项联合检测在小儿呼吸道疾病诊断中的应用价值分析 预览

The value of combined detection of high-sensitivity C reactive protein,procalcitonin and interleukin-10 in the diagnosis of respiratory diseases in children:a report of three cases
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摘要 目的探讨超敏C反应蛋白、降钙素原以及白细胞介素-103项联合检测在小儿呼吸道疾病诊断中的应用价值。方法选取本院儿科2016年12月至2017年12月间收治的呼吸道感染性疾病患儿80例为研究对象。根据实验室病毒血清学检验结果及细菌鉴定结果将80例患儿分为细菌感染组(36例)和病毒感染组(44例),同时,选取本院同期健康体检小儿40例作为对照组。分别两组小儿的血清hs-CRP、PCT、IL-10水平进行检测并采用ROC曲线评价各项检测结果的临床意义。结果细菌感染组hs-CRP、PCT水平显著高于病毒感染及对照组,IL-10水平明显低于病毒感染及对照组(P<0.05);病毒感染组与对照组hs-CRP、PCT、IL-10水平比较差异无统计学意义;hs-CRP、PCT、IL-10最佳截值分别为16.78mg/L、0.85nmol/ml及10.28ng/L;3项联合检测的AUC、敏感度、特异度、阳性、阴性预测值及约登指数与PCT比较差异无统计学意义,其诊断效能均明显高于hs-CRP、IL-10(P<0.05)。结论hs-CRP、PCT及IL-103项联合检测对小儿呼吸道疾病的诊断价值与PCT单独检测相当,两者均可作为小儿呼吸道疾病早期预防及临床诊断的重要手段。 Objective To explore the diagnostic value of combined detection of high sensitivity C reactive protein,procalcitonin and interleukin-10 in three children with respiratory diseases.Methods 80 children with respiratory tract infections admitted in our hospital from December 2016 to December 2017 were selected as the research subjects.80 children were divided into bacterial infection group(36 cases)and virus infection group(44 cases)according to the results of laboratory virus serological test and bacterial identification.At the same time,40 cases of healthy children in our hospital were selected as control group.Serum hs-CRP,PCT and IL-10 levels were detected in each group,and the clinical significance of the test results was evaluated by ROC curve.Results The level of hs-CRP and PCT in the bacterial infection group was significantly higher than that of the virus infection and the control group.The level of IL-10 was significantly lower than that of the virus infection and the control group(P<0.05).The levels of hs-CRP,PCT and IL-10 in the virus infection group and the control group were not significantly different,and the best cut-off values of hs-CRP,PCT and IL-10 were 16.78 mg/L and 0.85 nmol/ml and 10.28 ng/L;AUC,sensitivity,specificity,positive,negative predictive value and AUC index were similar to that of PCT,and their diagnostic efficiency was significantly higher than that of hs-CRP and IL-10 two groups(P<0.05).Conclusion The diagnostic value of 3 combined tests of hs-CRP,PCT and IL-10 for children with respiratory diseases is equal to that of PCT alone.The 2 can be used as an important means of early prevention and clinical diagnosis of respiratory diseases in children.
作者 郑玉花 Zheng Yuhua(Department of Paediatrics,Zaozhuang Mining Group Tengnan hospital,Jining,Shandong,277606,China)
出处 《当代医学》 2019年第5期15-17,共3页 Contemporary Medicine
关键词 HS-CRP PCT IL-10 小儿呼吸道疾病 临床检测 hs-CRP PCT IL-10 Pediatric respiratory diseases Clinical detection
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