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改良根治术与保乳手术治疗早期乳腺癌患者的近远期疗效对照比较 预览

Comparative study of short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer
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摘要 目的 比较改良根治术与保乳手术治疗早期乳腺癌患者的近远期疗效。方法 收集2011年6月至2014年1月早期乳腺癌的患者134例,采用随机数字表法将其分为根治组与保乳组,分别采用改良根治术与保乳手术进行治疗,采用SPSS19.0软件进行分析,术中术后指标和生活质量评分采用均数±标准差进行描述,采用独立t检验;1年和3年总生存率和无病生存率、并发症采用率进行描述,采用χ^2检验;采用log-rank检验法对两组患者的生存率进行检验,检验水准为α=0.05。结果 根治组患者术中的平均出血量低于保乳组,且手术时间和术后的平均住院天数均少于保乳组,根治组患者的生理职能和精神健康得分低于保乳组,差异均具有统计学意义(P<0.05);根治组患者的3年无病生存率和3年总生存率均高于保乳组(P<0.05);根治组患者的腋窝淋巴结转移率低于保乳组,差异具有统计学意义(P<0.05)。结论 改良根治术治疗早期乳腺癌患者的近期疗效和远期疗效均优于保乳手术,腋窝淋巴结的转移率低于保乳手术,更为安全有效,推荐在临床上使用。 Objective To compare the short-term and long-term clinical outcome of modified radical mastectomy and breast conserving surgery in treating early staging breast cancer. Methods 134 patients with early staging breast cancer were enrolled into this study,including radical group and breast conserving group by using random number table method.Clinical data were analyzed by using statistical software SPSS 19.0.Measurement data such as perioperative indicators and life quality score were expressed as mean±standard deviation,and independent t test was used for comparison between the groups.Count data,such as 1 year-,3 year-OS/DFS and postoperative complication rate were examined by usingχ2 and log-rank test(α=0.05).A P value<0.05 was considered as statistically significant difference. Results The average blood loss in the radical group was lower than that in the breast conserving group,and the operation time and the average postoperative hospital stay were less than those in the breast conserving group,the scores of physiological function and mental health in the radical group were lower than those in the breast conserving group,with significant differences(P<0.05);the 3-year disease-free survival rate and the 3-year overall survival rate in the radical group were higher than those in the breast conserving group,with significant differences(P<0.05);the axillary lymph node metastasis rate in the radical group was lower than that in the breast conserving group,with significant difference(P<0.05). Conclusion The short-term and long-term clinical outcome of modified radical mastectomy for breast cancer patients are better than breast conserving surgery,the axillary lymph node metastasis rate is lower than the breast conserving surgery.It is safer and more effective and worth of clinical promotion.
作者 朱辉琴 陈卫军 朱建华 胡阳英 汪海波 Zhu Huiqin;Chen Weijun;Zhu Jianhua;Hu Yangying;Wang Haibo(Department of general surgery,Dongtai people’s Hospital,Zhejiang 224200,China;Department of general surgery,Zhejiang University International Hospital,Zhejiang 310000,China;Department of oncology,the First Affiliated Hospital,Zhejiang University,Zhejiang 310000,China)
出处 《中华普外科手术学杂志(电子版)》 2019年第1期48-50,共3页 Chinese Journal of Operative Procedures of General Surgery(Electronic Version)
基金 浙江省医药卫生一般研究计划(B类)(2015KYB159).
关键词 乳腺肿瘤 乳房切除术 改良根治性 乳房切除术 区段 疗效比较研究 Breast neoplasms Mastectomy,modified radical Mastectomy,segmental Comparative effectiveness research
作者简介 通信作者:朱辉琴,Email:zxbjtr@163.com
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  • 1中国抗癌协会乳腺癌诊治指南与规范(2011版)[J].中国癌症杂志,2011(5):367-417. 被引量:154
  • 2张保宁 ,邵志敏 ,乔新民 ,李波 ,姜军 ,杨名添 ,王水 ,宋三泰 ,张斌 ,杨红健 .中国乳腺癌保乳治疗的前瞻性多中心研究[J].中华肿瘤杂志,2005,27(11):680-684. 被引量:229
  • 3ZFisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of arandomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med, 2002, 347:1233-1241. 被引量:1
  • 4Veronesi U, Caseinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical masteetomy for early breast cancer. N Engl J Med, 2002, 347 : 1227-1232. 被引量:1
  • 5Ganz P, Kwan L, Stanton AL, et al. Quality of life at the end of primary treatment of breast cancer: first results from the moving beyond cancer randomized trial. J Natl Cancer Inst, 2004, 96: 376-387. 被引量:1
  • 6Du X, Freeman DH Jr, Syblik DA. What drove changes in the use of breast conserving surgery since the early 1980s? The role of the clinical trial, celebrity action and an NIH consensus statement. Breast Cancer Res Treat, 2000, 62:71-79. 被引量:1
  • 7Katipamula R, Degnim AC, Hoskin T, et al. Trends in mastectomy rates at the Mayo Clinic Rochester: effect of surgical year and preoperative magnetic resonance imaging. J Clin Oncol, 2009, 27:4082-4088. 被引量:1
  • 8McGure KP, Santillan AA, Kanr P, et al. Are mastectomies on the rise.'? A 13-year trend analysis of the selection of mastectomy vsrsus breast conservation therapy in 5865 patients. Ann Surg Oncol, 2009, 16:2682-2690. 被引量:1
  • 9Tuttle TM, I-Iabermann EB, Grund EH, et al. Increasing use of contralateral prophylactic mastectomy for breast cancer patients: a trend toward more aggressive surgical treatment. J Clin Oncol, 2007, 25:5203-5209. 被引量:1
  • 10Fisher B, Jeong J H, Anderson S, et al.Twenty-five-year follow-up of a randomized trial comparing radicalmastectomy, total mastectomy, and total mastectomy fol lowed by irradiation[J].N Engl Med, 2002, 347 (152) :567-575. 被引量:1

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