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喘可治注射液联合布地奈德气雾剂治疗支气管哮喘急性发作患者的疗效及对患者炎性反应递质和肺功能的影响 预览

Effects of Chuankezhi Injection Combined with Budesonide Aerosol in the Treatment of Acute Attack of Bronchial Asthma and its Influence on Inflammatory Mediators and Pulmonary Function
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摘要 目的:探讨喘可治注射液联合布地奈德气雾剂治疗支气管哮喘急性发作患者的疗效及对患者炎性反应递质和肺功能的影响。方法:选取2014年12月至2016年12月资阳市第一人民医院收治的哮喘急性发作患者84例,依据随机对照试验(单盲法)分为观察组和对照组,每组42例。观察组采用喘可治注射液联合布地奈德气雾剂治疗,对照组单纯采用布地奈德气雾剂治疗。2组疗程均为7d。比较2组疗效,主要症状体征评分、炎性反应递质及肺功能变化。结果:观察组总有效率(92.86%)高于对照组(69.05%),差异有统计学意义(P<0.05);治疗后观察组咯痰、喘息、咳嗽、哮鸣音评分低于对照组,差异有统计学意义(P<0.05);治疗后观察组白细胞介素-4(IL-4)、免疫球蛋白E(IgE)水平低于对照组而干扰素-γ(IFN-γ)水平高于对照组,差异有统计学意义(P<0.05);治疗后观察组FEV1占预计值、用力肺活量、呼气峰流量高于对照组,差异有统计学意义(P<0.05)。结论:喘可治注射液联合布地奈德气雾剂治疗支气管哮喘急性发作患者疗效显著,且可改善患者炎性反应递质和肺功能。 Objective:To investigate the effects of Chuankezhi injection combined with budesonide aerosol in the treatment of acute attack of bronchial asthma and its influence on inflammatory mediators and pulmonary function.Methods:A total of 84 patients with acute attack of asthma in the First People's Hospital of Ziyang from December 2014 to December 2016 were divided into control group and observation group with 42 cases in each group according to random table method.The observation group was treated with Chuankezhi injection combined with budesonide aerosol.The control group was only treated with budesonide aerosol.The two groups were treated for 7 days.The two groups were compared with the main symptoms and signs score,inflammatory mediators and pulmonary function changes before and after treatment.Results:The total efficiency of the observation group (92.86%) was higher than the control group (69.05%)(P<0.05) with statistically significance.The phlegm,wheezing,cough,wheezing score in the observation group were lower than the control group (P<0.05).Interleukin-4 (IL-4) and immunoglobulin E (IgE) levels after treatment in the observation group were lower than that of control group,but Interferon-γ(IFN-γ) level was higher than that of control group with statistically significance (P<0.05).The forced expiratory volume in one second (FEC1) for predicted value,forced vital capacity and peak expiratory flow in the observation after treatment was higher than that of control group (P<0.05).Conclusion:The treatment of acute attack of bronchial asthma with Chuankezhi injection combined with Budesonide Aerosol is effective,and it can improve the inflammatory mediators and lung function,which has important research significance.
作者 朱建军 张远军 朱建华 张林 Zhu Jianjun;Zhang Yuanjun;Zhu Jianhua;Zhang Lin(Department of Emergency,the First People's Hospital of Ziyang,Ziyang Hospital of West China Hospital Sichuan University,Ziyang 641300,China;The Affiliated Hospital of Southwest Medical University,Luzhou 646000,China)
出处 《世界中医药》 CAS 2019年第1期158-161,共4页
基金 四川省教育厅科研项目(17ZB0134).
关键词 喘可治注射液 布地奈德气雾剂 支气管哮喘 急性发作 疗效 症状体征评分 炎性反应递质 肺功能 Chuankezhi injection Budesonide aerosol Bronchial asthma Acute attack Therapeutic effect Symptoms and signs score Inflammatory mediators Pulmonary function
作者简介 朱建军(1979.10-),男,本科,副主任医师,研究方向:内科危重症患者的救治,E-mail:zhujianjun@126.com
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