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中国人群血清尿酸与高血压相关 预览

The serum uric acid is related to hypertension in Chinese population
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摘要 目的探讨中国人群血清尿酸与高血压相关性。方法收集2007至2011年进行的中国人群生理常数调查数据,共22983例(男10787例,女12796例),按照是否患有高血压分为高血压组和非高血压组。入组对象均进行体格检查及生化指标检测,两组间比较用非参数秩和检验(Mann-WhitneyU),两组间率的比较用卡方(χ^2)检验。结果总高尿酸血症(HUA)患病率为13.0%(2977/20006),高血压组HUA患病率显著高于非高血压组(18.3%vs11.2%,P<0.05)。不同性别均表现为HUA组高血压患病率高于non-HUA组(男:38.2%vs26.0%,P<0.05;女:37.4%vs20.2%,P<0.05)。按照年龄分组,两组均显示45岁以后随着年龄增加,HUA患病率呈升高趋势。汉、回、蒙古、朝鲜、藏、土家和其他民族均显示高血压组HUA患病率明显高于非高血压组。结论血清尿酸水平与高血压患病率呈正相关。 Objective To explore the relationship between serum uric acid and hypertension in Chinese population.Methods A total of 22983 individuals (10787 males and 12796 females) were collected from 2007 to 2011 derived from the Chinese Physiological Constant and Health Condition (CPCHC) survey and were divided into hypertension group and non-hypertension group according to whether they had hypertension or not.Physical examination and biochemical tests were performed in both groups.Mann-Whitney U test was used to compare the two groups.Chi square test was used to compare the two groups.Results The prevalence of total hyperuricemia(HUA) was 13.0%(2977/20006),the prevalence of HUA in hypertension group was much higher than that in non-hypertension group(18.3% vs 11.2%,P<0.05).The prevalence of hypertension in HUA group was significantly higher than in non-HUA group(male:38.2% vs 26.0%,P<0.05;female:37.4% vs 20.2%,P<0.05).The prevalence of HUA in hypertension group was significantly higher than that in non-hypertension group by age,and the prevalence of HUA increased with age after 45 years in both groups.The prevalence of HUA in Han,Hui,Mongolia,North Korea,Tibet,Tujia and other ethnic groups was significantly higher than non-hypertension group.Conclusions Serum uric acid level is potentially related to the prevalence of hypertension.
作者 王丹晨 尹逸丛 邱玲 吴洁 禹松林 侯立安 李洪雷 由婷婷 国秀芝 程歆琦 WANG Dan-chen;YIN Yi-cong;QIU Ling;WU Jie;YU Song-lin;HOU Li-an;LI Hong-lei;YOU Ting-ting;GUO Xiu-zhi;CHENG Xin-qi(Department of Laboratory Medicine,Peking Union Medical College Hospital,CAMS & PUMC,Beijing 100730,China)
机构地区 中国医学科学院
出处 《基础医学与临床》 CSCD 2019年第2期182-186,共5页 Basic Medical Sciences and Clinics
基金 国家科技部科技基础性工作专项项目资金(2006FY110300) 公益性行业(健康)科研专项基金(201502024).
关键词 血清尿酸 高血压 观察性研究 serum uric acid hypertension observation study
作者简介 通信作者(corresponding author):邱玲,lingqiubj@aliyun.com
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