期刊文献+

急性脑梗死患者血清ox-LDL、Lp-PLA2水平变化及临床意义 预览

The changes and significance of serum Lp-PLA2 and ox-LDL in patients with acute cerebral infarction
在线阅读 下载PDF
收藏 分享 导出
摘要 目的观察脂蛋白相关磷脂酶A2(Lp-PLA2)及氧化低密度脂蛋白(ox-LDL)在急性脑梗死(ACI)患者中的变化及其意义。方法选取2015年1月~2018年1月123例在浙江省台州恩泽医疗中心(集团)恩泽医院就诊的初发ACI患者为观察组,另选取健康志愿者120例为对照组,对两组患者入院即刻,入院后12、24、72h时血清Lp-PLA2和ox-LDL水平进行检测。根据不同脑梗死严重程度,将观察组患者分为重度脑梗死组(n=34)、中度脑梗死组(n=52)和轻度脑梗死组(n=37),比较三组患者血清Lp-PLA2和ox-LDL水平。根据不同梗死面积,将观察组患者分为大梗死组(n=38)、中梗死组(n=49)和小梗死组(n=36),比较三组Lp-PLA2和ox-LDL水平变化。结果观察组患者入院即刻,入院后12、24、72h时血清Lp-PLA2和ox-LDL水平明显高于对照组,差异有统计学意义(P<0.05);且随着入院时间延长,观察组患者血清Lp-PLA2和ox-LDL水平呈先增后减趋势。重度脑梗死组Lp-PLA2和ox-LDL水平较中度、轻度脑梗死组升高(P<0.05),中度脑梗死组较轻度脑梗死组升高(P<0.05)。大梗死组Lp-PLA2和ox-LDL水平较中、小梗死组升高(P<0.05),中梗死组较小梗死组升高(P<0.05)。结论ACI患者血清Lp-PLA2和ox-LDL水平显著升高,可一定程度反映疾病严重程度,两者可作为血清标志物,在评估ACI的病情及预后中有积极意义。 Objective To observe the changes and significance of lipoprotein-associated phospholipase A2(Lp-PLA2)and oxidized low density lipoprotein(ox-LDL)in patients with acute cerebral infarction(ACI).Methods One hundred and twenty-three patients with initial ACI admitted in Taizhou Enze Medical Center(Group)Enze Hospital in Zhejiang Province from January 2015 to January 2018 were selected as the observation group,and 120 cases of healthy volunteers were selected as the control group.The levels of Lp-PLA2 and ox-LDL were detected immediately after admission and at 12,24,72 hours after admission.According to the severity of cerebral infarction,the patients in the observation group were divided into severe cerebral infarction group(n=34),moderate cerebral infarction group(n=52)and mild cerebral infarction group(n=37).The serum levels of Lp-PLA2 and ox-LDL were compared among the three groups.According to different infarct size,the patients in the observation group were divided into large infarction group(n=38),middle infarction group(n=49)and small infarction group(n=36).The changes of Lp-PLA2 and ox-LDL level were compared among the three groups.Results The serum levels of Lp-PLA2 and ox-LDL in the observation group were significantly higher than those in the control group at admission and 12,24,72 hours after admission,the differences were statistically significant(P<0.05).In addition,the serum Lp-PLA2 and ox-LDL levels in the observation group increased first and then decreased with the increase of admission time.The levels of Lp-PLA2 and ox-LDL in severe cerebral infarction group were higher than those in moderate and mild cerebral infarction group(P<0.05),and that in moderate infarction group was higher than that in mild cerebral infarction group(P<0.05).The levels of Lp-PLA2 and ox-LDL in the large infarction group were higher than those in the middle and small infarction group(P<0.05),and that in middle infarction group was higher than that in small infarction group(P<0.05).Conclusion The levels of serum Lp-PLA2 and
作者 洪卫军 黄琴 HONG Weijun;HUANG Qin(Department of Neurology,Taizhou Enze Medical Center (Group) Enze Hospital,Zhejiang Province,Taizhou 318053,China;Department of Otorhinolaryngology,Taizhou Hospital of Zhejiang Province,Zhejiang Province,Taizhou 317000,China)
出处 《中国医药导报》 CAS 2019年第5期72-75,共4页 China Medical Herald
基金 浙江省台州市科学技术局科技资金补助项目(15yw01)。
关键词 急性脑梗死 脂蛋白相关磷脂酶A2 氧化低密度脂蛋白 预后 Acute cerebral infarction Lipoprotein-associated phospholipase A2 Oxidized low density lipoprotein Prognosis
  • 相关文献

参考文献19

二级参考文献190

共引文献3299

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈