Objective To investigate the pregnancy outcomes of labetalol combined with magnesium sulfate in the treatment of gestational hypertension. Methods From August 2014 to March 2018, 120 pregnant women with pregnancy induced hypertension in obstetrics and gynecology were selected as the subjects. All the women were divided into the observation group of 40 cases and the control group 80 cases accorded to the different treatment methods, the control group were treated with magnesium sulfate, and the observation group were given the treatment of the labetalol combined with magnesium sulfate. Results After treatment, the mean arterial pressure of the two groups were showed significant downward trend and compared were significantly difference (P<0.05). After treatment, the observation group were also significantly lower than that of the control group and compared were significantly difference (P<0.05). The incidence of premature delivery, fetal distress and postpartum hemorrhage in the observation group were significantly lower than that in the control group and compared were significantly difference (P<0.05). Conclusion The labetalol combined with magnesium sulfate in the treatment of pregnant women with gestational hypertension can effectively control the mean arterial pressure and improve the outcome of pregnancy, which is worthy of popularization and application.