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基于共词分析法分析新生儿重症监护领域超药品说明书用药现状 预览

Status quo of the off-label drug use in neonatal intensive care: a co-word analysis
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摘要 目的探讨采用共词分析法对基于文献报道的国内外新生儿重症监护领域超药品说明书用药(OLDU)现状,旨在为该领域OLDU研究提供方向。方法本研究以“新生儿重症监护”“超说明书用药”为中文关键词,在中国知网(CNKI)数据库、万方数据库中进行文献检索;同时,以“neonatal intensive care”“off-labeldrug”为英文关键词,在MEDLINE数据库中进行检索。设定文献检索时间为各个数据库建库至2018年6月31日。选择由此获取的符合本研究纳入标准与排除标准的42篇新生儿童症监护领域OLDU相关文献为研究对象。其中,中文文献为3篇,英文文献为39篇。采用Microsoft Office Excel2016软件对39篇英文文献关键词进行录入、整理。由于该领域中文文献数量太少(3篇),无法建立中文文献的关键词共现矩阵,故仅对英文文献关键词进行提取。对纳入研究的39篇英文文献提取关键词后,继续采用该软件建立关键词共现矩阵,使用Ucinet6.2绘制关键词共现网络知识图谱,并进行新生儿重症监护领域OLDU共词分析。结果自纳入本研究的新生儿重症监护领域OLDU的39篇英文文献中,提取关键词共计18个,最早的文献发表于1999年,并且进行这方面研究文献的数量呈逐年升高趋势。新生儿重症监护领域OLDU英文文献关键词共现网络知识图谱显示,位于图谱中心的是“neonate(新生儿)”“off-labeldrug(超说明书药物)”和“preterm(早产儿)”;其次“audit(审查)”“antibiotic(抗菌药物)”“inhalednitricoxide(吸入一氧化氮)”也是较为热门关键词。此外,关键词“pharmacokinetics(药物代谢动力学)”的位置虽然偏离核心关键词,但是与关键词“neonate(新生儿)”的联系较为紧密(连线较粗)。结论新生儿重症监护领域OLDU相关问题并不少见,国外对该领域的关注时间较长、研究范围覆盖面较广。我国对该领域的研究处于起步阶段,目前需要加 Objective To analyse status quo of literatures on off-label drug use (OLDU) in the field of neonatal intensive care, aiming at discussing the research status and future prospects for OLDU in this field. Methods The Chinese National Knowledge Infrastructure (CNKI) databases, Wanfang database and MEDLINE database had been searched using the key words of "neonatal intensive care" and "off-label drug". And publication time of the literatures are databases construction until June 31, 2018. A total of 42 articles (3 Chinese and 39 English) in accordance with the accepting criteria of this study were included as the research objects. Key words of the included literatures were entered and collated by using Microsoft Office Excel 2016 software. The co-occurrence matrix was established by Excel 2016. Then Ucinet 6.2 was used to plot the knowledge map. Results In the 39 English-language literatures related to OLDU in the field of neonatal intensive care, 18 key words were included. The earliest published literature was published in 1999, and the number of related literatures in this field is increasing year by year. The co-word analysis of English literature key words revealed that "neonate""off-label drug" and "preterm" were the core in the research field of neonatal intensive care unit. Furthermore,"audit""antibiotic" and "inhaled nitric oxide" were also hot key words. In addition, the position of the key word "pharmacokinetics" was off-center, but it was also closely related to the key word "neonate". Conclusions OLDU is very common in the field of neonatal intensive care. Foreign countries have paid attention to this field for a long time and covered a wide range of research. Eyes are just beginning to be cast on OLDU in neonatal intensive care in China. At present, it is necessary to strengthen the attention and pay more attention to the OLDU in the field of neonatal intensive care. Relevant clinical trials should be carried out to ensure the safety of medication for neonatal patients in neonatal intensive care unit.
作者 孙飞扬 杨晓燕 胡艳玲 陈大鹏 石晶 唐军 Sun Feiyang;Yang Xiaoyan;Hu Yanling;Chen Dapeng;Shi Jing;Tang Jun(Department of Pediatrics,Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University),Ministry of Education,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China)
出处 《中华妇幼临床医学杂志(电子版)》 CAS 2019年第1期86-91,共6页 Chinese JOurnal of Obstetrics & Gynecology and Pediatrics
基金 国家临床重点专科建设项目(1311200003303) 国家自然科学基金青年基金资助项目(81300524) 四川省科技厅应用基础项目(2016JY0180) 四川省卫生计生委科研课题(150104、150107) 四川省科技厅应用基础项目(2011JY0085) 四川省医学科研青年创新课题(Q14036).
关键词 重症监护 新生儿 说明书 超说明书用药 共词分析 婴儿 新生 Intensive care, neonatal Prospectuses Off-label drug use Co-word analysis Infant, newborn
作者简介 通信作者:陈大鹏,Email:cdp415@163.com.
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