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2型糖尿病性骨质疏松骨质量改变研究 预览

Effect of type 2 diabetes mellitus on bone quality
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摘要 尽管糖尿病和骨质疏松症是两种不同的慢性代谢性疾病,但糖尿病患者由于血糖异常、胰岛素缺乏或不足、降糖药物应用等诸多因素,经常会影响骨量与骨质量,导致骨质疏松。因此,糖尿病性骨质疏松症(diabetic osteoporosis,DOP)已经被认定为糖尿病的慢性并发症之一。我国2型糖尿病患者众多,影响较之1型糖尿病更为广泛。多项临床研究显示,2型糖尿病性骨质疏松症、骨折风险增高的原因并非是骨密度的减少,而是多种原因导致的骨质量改变,主要包括骨结构与骨质材料属性等。本文就近年来2型糖尿病性骨质疏松骨质量改变相关的研究进展进行综述。 Although diabetes mellitus(DM)and osteoporosis are two different metabolic diseases,the risk of fragility fractures is increased in DM patients,due to the impact of dysglycemia,shortage of insulin secretion,useage of hypoglycemic drugs et al on both bone quality and quantity.Therefore the conception of diabetic osteoporosis(DOP)was proposed,and defined as another important complication of DM.As in China,type 2 DM(T2DM)has more significant influence on public health than T1DM.Previous researches had demonstrated that the underlying mechanisms of T2DM DOP couldn’t be explained by BMD,since BMD in T2DM is often normal or even slightly elevated as compared to age-matched control population.Therefore,alternation of bone material strength(BMS)and sone microstructure in T2DM dttract much more attention and many advances were achieved recently.The aim of the present review is to summarize theadvance mechanism of T2DM DOP due to changes of bone quality.
作者 杨蕾 付勤 YANG Lei;FU Qin(Orhopeadics Surgery Department of Shengjing Hosptial,China Medical University,Shanyang 110004,China)
出处 《中华骨质疏松和骨矿盐疾病杂志》 CSCD 北大核心 2019年第1期100-108,共9页
基金 国家自然科学基金(81370981)。
关键词 2型糖尿病性骨质疏松 骨微结构 骨细胞网状结构 糖基化终末产物 type 2 diabetes mellitus bone microstructure osteocyte network advanced glycation end products
作者简介 通信作者:付勤,E-mail:fuq@sj-hospital.org.
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