[Objective]To investigate the therapeutic effect of Mosapride combined with traditional Chinese medicine(Chai-qin-wen-dan-chengqi Decoction)on moderate severe acute pancreatitis(MSAP)complicating with intestinal paralysis.[Methods]A total of 90 patients with MSAP complicating with intestinal paralysis in the Department of Gastroenterology of The first people,s hospital of Kunming from August 2016 to December 2017 were enrolled in the study,which were selected and randomly divided into control group and study group,with 45 cases in each group.The control group received routine treatment,the study group was treated additionally with Mosapride plus traditional Chinese medicine(Chai-qin-wen-danchengqi Decoction)for oral and enema infusion.The relative indicators and curative effect of the two groups were observed and compared between two groups.[Results]In study group,the recovery time of bowel sound,the recovery time of restoring the anal defecation,the relief time of abdominal distension and pain,the decrease of mediators of inflammation and white blood cell,the recovery time of blood amylase and days of hospitalization were significantly shorter than the control group(P<0.05);the efficiency of healing intestinal paralysis was higher in study group(P<0.05).The score of three clinical diagnostic criteria systems[APACHE Ⅱ,Ranson and Balthazar CT severity index]were significantly lower than those in the control group(P<0.05).The difference was statistically significant(P<0.05).[Conclusion]Mosapride combined with traditional Chinese medicine(Chai-qin-wen-dan-chengqi Decoction)can effectively alleviate the intestinal paralysis of MSAP patients and avoid the deterioration of SAP,which is worthy of clinical promotion and application.
Chinese Journal of Clinical Gastroenterology
moderately severe acute pancreatitis
traditional Chinese medicine