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急性呼吸道感染常见病毒的流行病学分析 预览

Epidemiological analysis on common virus of acute respiratory tract infection
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摘要 目的了解7种常见呼吸道病毒感染的流行情况,为临床诊疗提供参考。方法回顾性分析福建医科大学附属南平第一医院2015年3月—2018年2月急性呼吸道感染(ARTI)患者的临床资料,采用直接免疫荧光法检测7种常见呼吸道病毒抗原。结果共纳入ARTI患者5874例。病毒检出阳性共1150例,检出率为19.58%。2015—2017年各年份检出率依次分别为11.48%、21.71%、21.54%。单一病毒感染患者1131例,占阳性患者的98.35%;混合感染患者19例,占阳性患者的1.65%。检测的7种常见病毒中,呼吸道合胞病毒(RSV)阳性率最高,为11.29%。不同年龄段ARTI患者病毒阳性检出率比较,差异有统计学意义(P<0.05)。~6月组呼吸道病毒检出率最高(26.37%),占阳性患者的39.83%。不同季节ARTI患者病毒阳性检出率比较,差异有统计学意义(P<0.05)。冬季呼吸道病毒阳性检出率最高,为25.01%,其次为秋季(23.23%)。不同临床诊断ARTI患者病毒阳性检出率比较,差异有统计学意义(P<0.05),其中支气管肺炎患者病毒阳性检出率最高(28.60%)。结论该院近3年ARTI病例中常见呼吸道病毒感染率逐年增高,7种呼吸道病毒感染中,以RSV感染最为常见。呼吸道病毒感染多发生在秋冬季,且以1岁以下儿童为主要感染人群,其主要临床表现为支气管肺炎。 Objective To understand the prevalence of infection caused by 7 common respiratory tract virus,and provide reference for clinical diagnosis and treatment.Methods Clinical data of patients with acute respiratory tract infection(ARTI)from March 2015 to February 2018 in Nanping First Hospital Affiliated to Fujian Medical University were retrospectively analyzed,antigens of 7 common respiratory virus were detected by direct immunofluorescence assay(DIA).Results A total of 5 874 ARTI patients were enrolled.The positive detection rate of virus was 19.58%(n=1 150).Detection rates in 2015-2017 were 11.48%,21.71%,and 21.54%respectively.1 131 patients(98.35%)were with single virus infection,19 patients(1.65%)were with mixed infection.Among 7 detected common virus,respiratory syncytial virus(RSV)had the highest positive rate(11.29%).There was significant difference in the positive detection rate of ARTI virus among different age groups(P<0.05).Respiratory virus detection rate was the highest in~6 months group(26.37%),accounting for 39.83%of the positive patients.Positive rate of ARTI patients in different seasons was significantly different(P<0.05).Positive detection rate of respiratory virus was the highest in winter(25.01%),followed by autumn(23.23%).There was significant difference in the positive detection rate of virus among ARTI patients with different clinical diagnosis(P<0.05),positive detection rate of virus in patients with bronchopneumonia was the highest(28.60%).Conclusion In the past three years,infection rate of common respiratory tract virus in ARTI patients increased year by year,RSV infection is most common among 7 respiratory tract virus infection.Respiratory tract virus infection mostly occur in autumn and winter,and children under the age of 1 year are the main infected population,bronchopneumonia is the main clinical manifestation.
作者 池细俤 高世华 张忠源 刘明杰 CHI Xi-di;GAO Shi-hua;ZHANG Zhong-yuan;LIU Ming-jie(Department of Clinical Laboratory,Nanping First Hospital Affiliated to Fujian Medical University,Nanping 353000,China;Department of Paediatrics,Nanping First Hospital Affiliated to Fujian Medical University,Nanping 353000,China)
出处 《中国感染控制杂志》 CAS CSCD 北大核心 2019年第4期320-325,共6页 Chinese Journal of Infection Control
关键词 急性呼吸道感染 呼吸道病毒 直接荧光免疫 病原学 acute respiratory tract infection respiratory tract virus direct immunofluorescence etiology
作者简介 池细俤(1971-),男(汉族),福建省南平市人,主任技师,主要从事临床微生物检验研究;通信作者:高世华E-mail:Gaosh999@163.com.
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