Intervertebral disc degeneration related diseases have become the main cause of chronic low back pain. There are many causes and complicated mechanisms of intervertebral disc degeneration, among which the biological role of annulus fibrosus in intervertebral disc degeneration has been paid more and more attention. However, the exact mechanism of degeneration has not been elucidated. At present, the most important treatment for intervertebral disc degeneration related diseases is to remove the degenerated disc tissue rather than the fundamental treatment for the degeneration process. Therefore, the biological treatment of the annulus fibrosus is an innovative treatment idea. With the development of modern molecular biology, cell engineering and genetic engineering techniques, the biotherapy of degenerative fiber loop has been initially developed, but many problems remain unresolved. In this article, the mechanism and biological treatment of fibrous ring degeneration were discussed.
Chinese Journal of Bone and Joint Surgery