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帕金森病与生物钟紊乱

Parkinson’s Disease and Circadian Rhythm Disorders
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摘要 帕金森病(PD)运动症状与非运动症状的日间波动,以及睡眠障碍的高发生率说明PD患者存在生物钟紊乱。生物钟紊乱可以表现为睡眠觉醒周期、激素分泌、运动静息周期、血压、心率变异等。生物钟紊乱与PD之间的关系日益受到业内学者的关注,近期研究表明生物钟紊乱或许是促进PD发展的原因之一,治疗生物钟紊乱将是治疗PD的新方向。 The high incidence of the fluctuation of motor and nonmotor symptoms and sleep disorders in Parkinson’s diseas( PD) suggest that it has circadian rhythm disorders. Circadian rhythm disorders can be manifested as sleep-wake cycle,hormone secretion,rset-activity rhythm,blood pressure,heart rate variability,and other changes. The relationship between them is getting more and more attention. Recent studies have shown that circadian rhythm disorders may be one of the reasons for the development of PD,the treatment of circadian rhythm disorders may be a new direction for the treatment of PD.
作者 唐晓慧 汪锡金 TANG Xiao-hui;WANG Xi-jin(Department of Neurology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092 , China)
出处 《中国临床神经科学》 2019年第2期209-215,共7页 Chinese Journal of Clinical Neurosciences
基金 国家自然科学基金资助项目(编号:81671273).
关键词 帕金森病 生物钟紊乱 治疗 Parkinson's disease circadian rhythm disorders treatment
作者简介 唐晓慧,在读硕士研究生,住院医师,主要从事神经变性疾病研究(帕金森病及阿尔茨海默病);通信作者:汪锡金,E-mail:wangxijin.xinhuamed.com.cn.
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  • 1张振馨,.帕金森病的诊断[J].中华神经科杂志,2006,39(6):408-409. 被引量:539
  • 2Jankovic J. Parkinson's disease: clinical features and diagnosis[J]. J Neurol Neurosurg Psychiatry,2008,79:368-376. 被引量:1
  • 3Kassiou M, Banati R, Holsinger RM, et al. Challenges in molecular imaging of Parkinson's disease: a brief overview[J]. Brain Res Bu11,2009,78:105-108. 被引量:1
  • 4Eckert T, Eidelberg D. Neuroimaging and therapeutics in movement disorders [J]. Neuro Rx,2005,2:361-371. 被引量:1
  • 5Bohnen NI, Kuwabara H, Constantine GM, et al.Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease[J]. Neurosci Lett,2007,424:185-189. 被引量:1
  • 6Asanuma K, Tang C, Ma Y, et al. Network modulation in the treatment of Parkinson' s disease[J]. Brain, 2006,129:2667-2678. 被引量:1
  • 7Wichmann T, DeLong MR. Pathophysiology of Parkinson's disease: the MPTP primate model of the human disorder[J]. Ann N Y Acad Sci,2003,991 : 199213. 被引量:1
  • 8Rodriguez-Oroz MC, Jahanshahi M, Krack P, et al. Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms[J]. Lancet Neurol,2009,8:1128-1139. 被引量:1
  • 9Antonini A, Benti R, De Notaris R, et al.123I-Ioflupane/SPECT binding to striatal dopamine transporter (DAT) uptake in patients with Parkinson's disease, multiple system atrophy, and progressive supranuclear palsy[J]. Neurol Sci,2003,24:149-150. 被引量:1
  • 10Ahlskog JE, Uitti ILl, O' Connor MK, et al. The effect of dopamine agonist therapy on dopamine transporter imaging in Parkinson's disease[J]. Mov Disord,1999,14:940-946. 被引量:1

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