[Objective]To observe the effect of intravenous injection of dezocine and midazolam on cough reflex induced by sufentanil before induction of general anesthesia.[Methods]200 cases of adult general anesthesia,ASA I or class II,were randomly divided into four groups: A,B,C,D.The incidence and intensity of cough before intubation were recorded,and the changes of SBP,DBP and HR before and after intubation were recorded.[Results]Compared with group C and D,the blood pressure and heart rate were significant lower in group A and B at 1 min time after injection of sufentanil(P<0.05),and no significant difference between the four groups at the remaining time points(P>0.05).Compared with group C and D,The incidence and intensity of cough were significant lower in group A and B(P<0.01).Compared with group B,the incidence and intensity of cough were significant lower in group A(P<0.05).[Conclusion]Intravenous injection of dezocine and midazolam can effectively reduce the incidence of cough induced by sufentanil during general anesthesia induction.
Journal of Henan University