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不明原因的自发流产与精子DNA损失的关系 预览

Relationship between unexplained spontaneous abortion and sperm DNA damage
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摘要 目的探讨一次不明原因流产与精子DNA损伤的关系。方法收集有一次不明原因流产史的患者作为实验组,同时以有正常妊娠史的患者为对照组,分别比较两组男方年龄、精子密度、精子活力、精液量和精子DNA断裂指数有无差异。以SPSS16.0为统计软件,进行独立样本的t检验。结果两组的精液量、精子密度及活力均无差异,实验组男方年龄小于对照组(P<0.05),但实验组的DFI要高于对照组(P<0.01)。结论本研究对照组年龄高于实验组,而DFI正好相反。这说明不明原因的自发流产与男方精子DFI密切相关,随着DFI的增加,流产风险增加。 Objective To investigate the relationship between unexplained abortion and sperm DNA damage. Methods Patients with a history of unexplained abortion were enrolled as an experimental group, and patients with a normal pregnancy history were used as a control group. The differences in age, sperm density, sperm motility, semen volume, and sperm DNA break index were compared between the two groups. The independent sample t test was performed using the statistical software of SPSS 16.0. Results There was no significant difference in semen volume, sperm density and motility between the two groups. The age of the male group in the experimental group was lower than that in the control group ( P <0.05), but the DFI of the experimental group was higher than that of the control group, and the difference was statistical significance ( P <0.01). Conclusion The age of the study control group was higher than that of the experimental group, while DNA fragmentation index DFI was the opposite, which indicated that unexplained spontaneous abortion was closely related to the male sperm DFI, and the risk of miscarriage may increase with the increase of DFI.
作者 刘成军 涂艳琴 王蔼明 商微 王伟周 李敏 沈玉良 LIU Chengjun;TU Yanqin;WANG Aiming;SHANG Wei;WANG Weizhou;LI Min;SHEN Yuliang(Reproductive Center,Xijiang Hospital,Zhaoqing 526000,China;Reproductive Center,Navy General Hospital,Beijing 100048,China)
出处 《广州医药》 2019年第2期54-57,共4页 Guangzhou Medical Journal
关键词 不明原因自发流产 精子DNA损伤 一次 DFI Unexplained spontaneous abortion Sperm DNA damage Once DNA fragmentation index
作者简介 通讯作者:涂艳琴,wujizhi2006@126.com.
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