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Approach to 2′-(Dialkylamino)-1-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 1,3-Oxazin-4-ones via Cyclization of Vilsmeier Salts withα-Hydroxy andβ-Carbonyl Amides

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摘要 A straiglitforward and efficient synthetic method of 2′-(dialkylammo)-l-alkyl-4′H-spiro[indoline-3,5′-oxazole]-2,4′-diones and 2-(dialkylamino)-5,6-dihydro-4H-naphtho[2,1-e][1,3]oxazin-4-one-derivatives have been developed from a-hydroxy andβ-carbonyl amides and various Vilsmeier salts.A wide range of heterocyclic compounds were obtained in excellent yields(up to 97%),which will provide promising candidates lor chemical biology and drug discovery.
出处 《高等学校化学研究:英文版》 SCIE CAS CSCD 2019年第2期216-220,共5页 Chemical Research in Chinese University
基金 the National Natural Science Foundation of China(No.51373067).
作者简介 Corresponding authors: DUAN Haifeng,Email:duanhf@jlu.edu.cn;Corresponding authors:LIN Yingjie,Email:linyj@jlu.edu.cn;.
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