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COPD急性加重期不同临床表型相关性分析 预览 被引量:1

Analysis on correlation among different clinical phenotypes in acute exacerbation of COPD
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摘要 目的探讨慢性阻塞性肺疾病(COPD)急性加重期患者不同表型相关指标的变化及其相关性。方法收集90例COPD急性加重期患者,慢性阻塞性肺疾病全球倡议(GOLD)分级Ⅰ级20例、Ⅱ级25例、Ⅲ级25例、Ⅳ级20例,检测血清超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6、T淋巴细胞亚群水平,分析不同分级之间上述指标的差异及其与慢性阻塞性肺疾病评估测试(CAT)评分和肺功能指标的相关性。结果血清hs-CRP、IL-6、CAT评分随肺功能分级增加而增加(P<0.05),CD4^+和CD4^+/CD8^+随肺功能分级增加而降低(P<0.05)。hs-CRP、IL-6与CD4^+、CD4^+/CD8^+、1s用力呼气容积(FEV1)、1s用力呼气容积占预计值百分比(FEV1%pred)、1s用力呼气容积占用力肺活量比值(FEV1/FVC)均呈负相关(P<0.01);CD4^+、CD4^+/CD8^+与FEV1、FEV1%pred、FEV1/FVC均呈正相关(P<0.01);CAT评分与hs-CRP、IL-6均呈正相关(P<0.01),与CD4^+、CD4^+/CD8^+、FEV1、FEV1%pred、FEV1/FVC均呈负相关(P<0.01)。结论血清hs-CRP、IL-6、T淋巴细胞亚群水平、CAT评分与COPD急性加重期严重程度密切相关。 Objective To investigate the changes and correlation of different phenotypic related indicators in the patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Ninety patients with AECOPD were collected,including 20cases of classⅠ,25cases of classⅡ,25cases of classⅢ and 20cases of classⅣaccording to the GOLD classification.The levels of serum hs-CRP,IL-6and T-lymphocyte subsets were measured.The differences of above indicators among different classes and their correlations with CAT scores and lung function indicators were analyzed.Results The serum hs-CRP and IL-6levels and CAT scores were increased with the lung function grade increase(P<0.05),and CD4^+ and CD4^+/CD8^+ were decreased with the lung function grade increase(P<0.05).The levels of serum hs-CRP and IL-6were negatively correlated with CD4^+,CD4^+/CD8^+,FEV1,FEV1%pred and FEV1/FVC(P<0.01);CD4^+ and CD4^+/CD8^+ were positively correlated with FEV1,FEV1%pred and FEV1/FVC(P<0.01);the CAT score was positively correlated with hs-CRP and IL-6(P<0.01),and negatively correlated with CD4^+,CD4^+/CD8^+,FEV1,FEV1%pred and FEV1/FVC(P<0.01).Conclusion Serum hs-CRP,IL-6,T-lymphocyte subsets levels and CAT scores are closely related to the severity of AECOPD.
作者 郭太平 孟凡亮 GUO Taiping;MENG Fanliang(Department of Respiratory Medicine,Affiliated Chaohu Hospital of Anhui Medical University,Hefei,Anhui 238000,China)
出处 《重庆医学》 CAS 2019年第6期976-979,共4页 Chongqing medicine
基金 2018年度安徽省高校自然科学研究项目基金(KJ2018A0667).
关键词 肺疾病 慢性阻塞性 C反应蛋白质 白细胞介素6 慢性阻塞性肺疾病评估测试量表 淋巴细胞亚群 呼吸功能试验 pulmonary disease,chronic obstructive C-reactive protein interleukin-6 COPD assessment test lymphocyte subsets respiratory function tests
作者简介 郭太平(1993-),在读硕士,主要从事慢性阻塞性肺疾病的研究;通信作者:孟凡亮,E-mail:13966337677@163.com.
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