期刊文献+

氧化应激对胎盘生命的影响 预览

Effects of Oxidative Stress on Placental Life
在线阅读 下载PDF
分享 导出
摘要 氧化应激不仅是氧化剂的产生与抗氧化剂防御系统之间的不平衡状态,也是众多细胞功能障碍和组织损伤的原因。氧化应激相关因子在多种疾病中发挥重要作用,通过多种途径调节细胞内环境稳定,维持细胞存活。近年研究发现,氧化应激与相关的氧化损伤是导致多种疾病的主要因素,氧化应激相关指标在妊娠特有疾病(如子痫前期、胎儿生长受限)孕妇的血清及胎盘滋养细胞中高度表达。氧化应激同时与肿瘤、高血压等多种慢性疾病有关,与多种疾病的发生、发展密切相关。氧化应激作为妊娠期特有疾病的“共同通路”被深入研究,其中氧化应激对胎盘功能的影响备受关注。分析与总结胎盘在不同缺氧状态下与妊娠相关疾病的关系,探索氧化应激相关因子是否具有预测作用,为围生期相关疾病的预防及诊疗提供新方向、新思路。 Oxidative stress is not only the imbalance between the generation of oxidants and the antioxidant defense system, but also the cause of various cell dysfunction and tissue damage. Oxidative stress related factors play an important role in a variety of diseases. It adjusts the homeostasis of intracellular environment through a variety of pathways. In recent years, studies have found that oxidative stress and the related oxidative damage is the main factor leading to many diseases. Indicators related to oxidative stress in pregnancy-specific diseases such as preeclampsia pregnancy and fetal growth restriction are highly expressed in maternal serum and trophoblast cells. Meanwhile, oxidative stress is involved in the pathogenesis of various chronic disorders such as cancer and hypertension. Oxidative stress, as a common pathway of pregnancy-specific diseases, has been deeply studied, among which the effect of oxidative stress on placental function has attracted much attention. This paper analyzes and summarizes the relationship between placenta and pregnancy-related diseases under different hypoxic conditions, to explore whether oxidative stress related factors have predictive effect for pregnancy-related disease prevention and treatment.
作者 国林林 赵慧栋 胡海燕(审校) GUO Lin-lin;ZHAO Hui-dong;HU Hai-yan(Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266000,China;Qingdao Municipal Hospital,Qingdao 266000,China)
出处 《国际妇产科学杂志》 CAS 2019年第2期185-188,共4页 JOURNAL OF INTERNATIONAL OBSTETRICS AND GYNECOLOGY
关键词 氧化性应激 胎盘 活性氧 自噬 先兆子痫 滋养细胞 Oxidative stress Placenta Reactive oxygen species Autophagy Pre-eclampsia Trophoblast cells
作者简介 通信作者:胡海燕,E-mail:haiyanhu2002@163.com.
  • 相关文献

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈