Objective To provide reference for the rational use of antibiotics through summarizing the screening of common Gram-positive bacteria resistance and antibiotics from January 2012 to December 2013. Methods All pathogens isolated from clinically sent samples from January 2012 to December 2013 in our hospital were collected. Drug sensitivity was performed using MIC method. And the number of antibacterial drugs from January to December 2012, January to December 2013 was recalled from the drug information management program of the hospital information system. The frequency of use was calculated and sorted through the use of antibacterial drugs and the corresponding intensity of use. The resistance rate of the top ranked Staphylococcus aureus and Staphylococcus epidermidis was screened according to 30%-40%, 40%-50%, 50%-75% and >75%. Results The use of antibiotics especially the fourth generation of cephalosporins in the top three hospitals showed a general decline. The monocyclic β-lactam decreased significantly, and the cephalosporins were mainly dominated by the first and second generation. The clinical use supervision of the third and fourth generation cephalosporins, glycopeptides and carbapenems were strengthened, which played a positive role in preventing the abuse of antibiotics. Among the common Gram-positive bacteria, Staphylococcus aureus and Staphylococcus epidermidis had good sensitivity to vancomycin, indicating that glycopeptide antibiotics were still the first choice for the treatment of multi-drug resistant grape infection. Conclusion This study provides technical support for the rational use of antibiotics in hospitals, and also provides data support for bacterial resistance and antimicrobial screening in Jilin.
Drug resistance monitoring