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健脾生髓膏方治疗化疗后癌因性疲乏的临床疗效观察 预览

Clinical Observation of Jianpi Shengsui Herbal Paste in Post-chemotherapy Cancer-related Fatigue
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摘要 背景癌因性疲乏(CRF)是肿瘤患者进行化疗过程中及化疗后最常见的不适症状之一,严重影响患者的生活质量、治疗进度。目前,其病理生理学机制尚不明确,也缺少广泛认可和有效的干预手段。目的观察健脾生髓膏方治疗化疗后CRF的临床疗效。方法选取2015年7月2 016年7月广州中医药大学第一附属医院肿瘤门诊或住院部符合研究标准的80例化疗后癌症患者,按照自愿原则将患者分为治疗组38例,对照组42例。治疗组给予化疗+健脾生髓膏方治疗,健脾生髓膏方3次/d,2 0 g/次,2 1 d为1个疗程;对照组给予化疗。观察并比较两组疲劳量表(FS-14)评分(包括躯体疲劳、脑力疲劳)、贫血情况、骨髓功能指标(血红蛋白水平和中性粒细胞计数)。结果FS-1 4总分与贫血情况呈正相关(rs=0.882,P<0.001)。两组轻度贫血患者治疗前、后躯体疲劳评分、脑力疲劳评分、FS-1 4总分比较,差异无统计学意义(P>0.05);对照组轻度贫血患者躯体疲劳评分、脑力疲劳评分、FS-14总分组内治疗前后比较,差异无统计学意义(P>0.05);治疗组轻度贫血患者躯体疲劳评分、FS-1 4总分组内治疗前后比较,差异无统计学意义(P>0.05);治疗组轻度贫血患者脑力疲劳评分组内治疗前后比较,差异有统计学意义(P<0.05)。治疗前两组中度贫血患者躯体疲劳评分、脑力疲劳评分、FS-14总分比较,差异无统计学意义(P>0.05);治疗后两组中度贫血患者躯体疲劳评分比较,差异有统计学意义(P<0.05);治疗后两组中度贫血患者脑力疲劳评分、FS-1 4总分比较,差异无统计学意义(P>0.05)。对照组中度贫血患者躯体疲劳评分组内治疗前后比较,差异有统计学意义(P<0.05);对照组中度贫血患者脑力疲劳评分、FS-14总分组内治疗前后比较,差异无统计学意义(P>0.05);治疗组中度贫血患者躯体疲劳评分、FS-1 4总分组内治疗前后比较,差异有统计学意义(P<0.05);治疗组� Background Cancer-related fatigue(CRF)is one of the most common uncomfortable symptoms experienced by cancer patients during and after chemotherapy,which seriously affects their quality of life and treatment progress.At present,its pathophysiological mechanism is not clear,and there is a lack of widely recognized and effective interventions.Objective To observe the clinical efficacy of Jianpi Shengsui Herbal Paste for post-chemotherapy cancer-related fatigue.Methods In the tumor outpatient or impatient department of First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from July 2015 to July 2016,a total of 80 patients with post-chemotherapy cancer-related fatigue who met the research criteria were selected and divided into two groups in the principle of voluntariness,with 38 cases in the treatment group and 42 patients in the control group.Patients in the treatment group received chemotherapy and Jianpi Shengsui Herbal Paste,which was given 3 times/day and 20 g/time,with 21 days as a course and totally 2 courses.Patients in the control group received chemotherapy only,with 21 days as a course,and totally 2 courses.The Fatigue Scale(FS-14)scores(physical fatigue score,mental fatigue score,FS-14 total score),anemia condition and marrow function indexes(hemoglobin level and neutrophil count)were observed and compared during the process.Results There was a positive correlation between FS-14 total score and anemia(rs=0.882,P<0.001).For patients with mild anemia in the two groups,the differences of their physical fatigue score,mental fatigue score and FS-14 total score before and after treatment showed no statistical significance(P>0.05);for patients with mild anemia in the control group,the differences of their physical fatigue score,mental fatigue score and FS-14 total score before and after treatment showed no statistical significance(P>0.05);and for patients with mild anemia in the treatment group,the differences of their physical fatigue score and FS-14 total score before and after tre
作者 詹萍萍 余玲 林洁涛 林丽珠 ZHAN Pingping;YU Ling;LIN Jietao;LIN Lizhu(Macau University of Science and Technology,Macau 999078,China;First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,China)
出处 《中国全科医学》 CAS 北大核心 2019年第15期1855-1859,共5页 Chinese General Practice
基金 广东省中医药局建设中医药强省项目(20141082).
关键词 疲劳 膏剂 癌因性疲乏 化放疗 治疗结果 Fatigue Herbal paste Cancer-related fatigue Chemoradiotherapy Treatment outcome
作者简介 通信作者:林丽珠,博士生导师;E-mail:linlizhu903@21cn.com.
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