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不同环糊精对角鲨烯的包合作用

Inclusion of Squalene with Different Cyclodextrins
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摘要 角鲨烯是一种含有6个非共轭双键的直链三萜,其生理功能显著,但因水溶性及稳定性较差,限制了其应用。采用相溶解度法,在25、40和55℃下,考察了α-环糊精、β-环糊精、γ-环糊精、羟丙基-β-环糊精及甲基-β-环糊精对角鲨烯的包合作用,绘制相溶解图并计算包合过程中的热力学参数。结果表明:各相溶解图均为AL型,且γ-环糊精的包合效果及增溶效果最为显著。γ-环糊精对角鲨烯的包合常数(K)最大可达1778.0860 L/mol,最大可将角鲨烯的溶解度增大至原来的309.0935倍。包合过程中的热力学参数焓变(ΔH)及熵变(ΔS)均为正值,而吉布斯自由能(ΔG)均为负值,表明包合过程为吸热的自发反应,且无序化增加(熵增加)是环糊精空腔包封角鲨烯分子的主要驱动力。 Squalene is a linear triterpenoid with six non-conjugated double bonds. Its physiological function is remarkable, but its application is limited due to its poor water solubility and stability. The interactions between squalene and different cyclodextrins, including α-cyclodextrin,β-cyclodextrin,γ-cyclodextrin,hydroxypropyl-β-cyclodextrin and methyl-β-cyclodextrin were studied by phase solubility method at different temperatures(25, 40 and 55 ℃). The phase dissolution diagrams were plotted and the thermodynamic parameters during the inclusion process were calculated. The results showed that all phase dissolving diagrams were AL type. The inclusion effect and solubilization effect of γ-cyclodextrin were the most remarkable. The inclusion constant K of γ-cyclodextrin for squalene was up to 1778.0860 L/mol, and the solubility of squalene increased to 309.0935 times. The thermodynamic parameters enthalpy change(ΔH) and entropy change(ΔS) of the inclusion process were both positive values, while Gibbs free energy(ΔG) were both negative values, indicating that the inclusion process was an endothermic spontaneous reaction, and the increase of disorder(entropy increase) was the main driving force for the encapsulation of squalene molecules in cyclodextrin cavities.
作者 张光杰 杜磊 路志芳 袁超 陈笛 ZHANG Guang-jie;DU Lei;LU Zhi-fang;YUAN Chao;CHEN Di(School of Biotechnology and Food, Anyang Institute of Technology, Anyang 455000, Henan, China;School ofFood Science and Engineering, Qilu University of Technology, Jinan 250353, Shandong, China)
出处 《精细化工》 EI CAS CSCD 北大核心 2019年第4期703-707,共5页 Fine Chemicals
基金 国家自然科学基金项目(31571881) 河南省科技攻关项目(172102110003).
关键词 相溶解度 环糊精 角鲨烯 包合作用 食品化学品 phase solubility cyclodextrin squalene inclusion food chemicals
作者简介 张光杰(1982—),男,博士生,讲师,E-mail:65671385@qq.com。
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