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分泌性中耳炎患者外周血Th1Th2细胞及T淋巴细胞亚群水平的表达及临床意义

Expression and Clinical Significance of Peripheral Blood Th1Th2 Cells and T Lymphocyte Subsets Subgroups in Patients with Secretory Otitis Media
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摘要 目的:探讨分泌性中耳炎(SOM)患者外周血T辅助细胞1(Th1)、T辅助细胞2(Th2)细胞因子及T淋巴细胞亚群水平的表达及其临床意义。方法:选取我院于2015年1月至2018年1月期间收治的SOM患者135例记为SOM组,根据病程将患者分为急性组(病程<14d,49例)、亚急性组(病程14-30d,53例)、慢性组(病程>30d,33例)。另外选择同期于我院进行体检的100例健康者为对照组。分别对比SOM组和对照组受试者、不同病程SOM患者外周血Th1细胞因子[干扰素(INF-γ)、白细胞介素-2(IL-2)]、Th2细胞因子[白细胞介素-4(IL-4)、白细胞介素-10(IL-10)]以及T淋巴细胞亚群[CD3^+、CD4^+、CD8^+、CD4^+/CD8^+]水平。采用Pearson相关性分析INF-γ、IL-2、IL-4、IL-10与CD3^+、CD4^+、CD8^+、CD4^+/CD8^+的相关性。结果:SOM组患者外周血INF-γ、IL-2、IL-4、IL-10水平高于对照组(P<0.05);急性组患者外周血INF-γ、IL-2、IL-4、IL-10水平低于亚急性组、慢性组,亚急性组患者外周血INF-γ、IL-2、IL-4、IL-10水平低于慢性组(P<0.05)。SOM组患者外周血CD3^+、CD4^+、CD4^+/CD8^+水平低于对照组,CD8^+水平高于对照组(P<0.05);急性组患者外周血CD3^+、CD4^+、CD4^+/CD8^+水平高于亚急性组、慢性组,CD8^+水平低于亚急性组、慢性组,亚急性组患者外周血CD3^+、CD4^+、CD4^+/CD8^+水平高于慢性组,CD8^+水平低于慢性组(P<0.05)。Pearson相关性分析结果显示,SOM患者外周血INF-γ、IL-4与CD8^+呈正相关(P<0.05),IL-4与CD3^+、CD4^+呈负相关(P<0.05)。结论:SOM患者外周血Th1Th2细胞因子、T淋巴细胞亚群水平均表现异常,且其水平与疾病发生和发展存在一定联系,通过监测Th1Th2细胞因子、T淋巴细胞亚群有助于评估SOM患者病情。 Objective:To investigate the expression and clinical significance of T helper cell 1(Th1),T helper cell 2(Th2)cytokines and T lymphocyte subsets in peripheral blood of patients with secretory otitis media(SOM).Methods:135 patients with SOM who were admitted to our hospital from January 2015 to January 2018 were selected as SOM group.According to the course of disease,the patients were divided into acute group(the duration<14 d,49 cases),subacute group(the duration of 14-30 d,53 cases)and chronic group(the duration>30 d,33 cases).100 healthy patients who had physical examination in the outpatient department of our hospital were selected as the control group.The levels of peripheral blood Th1 cytokines[interferon(INF-γ),interleukin-2(IL-2)],Th2 cytokines[interleukin-4(IL-4),interleukin-10(IL-10)]and T lymphocyte subsets[CD3^+,CD4^+,CD8^+,CD4^+/CD8^+]were compared between SOM group and control group,and patients with different course of SOM.Pearson correlation analysis was performed on the correlation between IFN-γ,IL-2,IL-4,IL-10 and CD3^+,CD4^+,CD8^+,CD4^+/CD8^+.Results:The levels of peripheral blood IFN-γ,IL-2,IL-4 and IL-10 in the SOM patients were higher than those of the control group(P<0.05).The levels of peripheral blood INF-γ,IL-2,IL-4 and IL-10 in the acute group were lower than those of the subacute group and the chronic group.The levels of peripheral blood INF-γ,IL-2,IL-4 and IL-10 in the subacute group were lower than those of chronic group(P<0.05).The levels of peripheral blood CD3^+,CD4^+and CD4^+/CD8^+in the SOM patients were lower than those in the control group,and the levels of CD8^+were higher than those in the control group(P<0.05).The level of CD3^+,CD4^+and CD4^+/CD8^+in the acute group were higher than those in the subacute group and chronic group.The level of CD8^+in the acute group were lower than that in the subacute group and chronic group.The levels of CD3^+,CD4^+and CD4^+/CD8^+in the subacute group were higher than those in the chronic group.The level of CD8^+was lower than that of
作者 余巧 盛宏申 郭晓静 李平 刘文峰 何馨 YU Qiao;SHENG Hong-shen;GUO Xiao-jing;LI Ping;LIU Wen-feng;HE Xin(Department of ENT,Chengdu Military General Hospital ofPLA,Chengdu,Sichuan,610000,China)
出处 《现代生物医学进展》 CAS 2019年第6期1103-1107,共5页 Progress in Modern Biomedicine
基金 四川省科技计划项目(18ZDYF0491).
关键词 分泌性中耳炎 TH1细胞 TH2细胞 T淋巴细胞亚群 表达 临床意义 Secretory otitis media Th1 cells Th2 cells T lymphocyte subsets Expression Clinical significance
作者简介 余巧(1983-),女,本科,主治医师,从事耳鼻咽喉头颈外科方面的研究,E-mail:yphtfn@163.com;通讯作者:盛宏申(1970-),男.博七,副主任医师,从事耳鼻咽喉头颈外科方面的研究,E-mail:ffhcgb@163.com.
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