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清热化湿养阴生肌法治疗复发性口腔溃疡的疗效观察

Clinical Observation on Recurrent Oral Ulcer Treated with Therapy of Clearing Heat and Removing Dampness,Nourishing Yin and Promoting Granulation
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摘要 【目的】观察清热化湿、养阴生肌法治疗复发性口腔溃疡(ROU)湿热久羁、气阴两虚型患者的临床疗效。【方法】将64例湿热久羁、气阴两虚型ROU患者随机分为观察组33例和对照组31例。观察组给予清热化湿、养阴生肌法(药物组成:苦参、黄芩、黄连、青黛、防风、半夏、黄芪、大枣、珍珠、甘草)治疗,对照组给予外涂素高捷疗口腔软膏和小剂量的干扰素治疗,1周为1个疗程,共治疗2~4个疗程。观察2组患者治疗前后总溃疡数、溃疡发作总间歇时间、中医证候评分及局部症状体征评分的变化情况,评价2组的疗效和安全性。【结果】(1)经治疗2~4个疗程后,观察组的总有效率为90.91%,对照组为74.20%,观察组的疗效优于对照组(P<0.05)。(2)治疗后,2组患者的总溃疡数均较治疗前明显减少(P<0.05或P<0.01),溃疡发作总间歇时间均较治疗前明显延长(P<0.01),且观察组在减少总溃疡数和延长溃疡发作总间歇时间方面疗效优于对照组(P<0.05或P<0.01)。(3)治疗后,观察组患者的体倦少气、口干口渴、小便短赤等各项中医证候评分及溃疡疼痛、灼烧感、充血面积、溃疡面积、渗出面积等各项局部症状体征评分均较治疗前明显下降(P<0.01),而对照组患者的各项中医证候评分和局部症状体征评分均下降不明显(P>0.05);组间比较,观察组在改善各项中医证候评分和局部症状体征评分方面疗效均优于对照组(P<0.01)。(4)治疗期间,2组患者均无恶心、乏力、嗜睡等不良反应情况发生。【结论】清热化湿、养阴生肌法是治疗湿热久羁、气阴两虚型ROU的有效方法。 Objective To observe the curative effect of therapy of clearing heat and removing dampness,nourishing Yin and promoting granulation for the treatment of recurrent oral ulcer(ROU)with the syndrome of Qiyin deficiency due to long-time retention of dampness and heat. Methods Sixty-four ROU patients with the syndrome of Qi-yin deficiency due to long-time retention of dampness and heat were randomly divided into observation group(33 cases)and control group(31 cases). The observation group was treated with therapy of clearing heat and removing dampness, nourishing Yin and promoting granulation by using the herbs of Radix Sophorae Flavescentis,Radix Scutellariae,Rhizoma Coptidis,Indigo Naturalis,Radix Saposhnikoviae,Rhizoma Pinelliae,Radix Astragali,Fructus Jujubae,Margarita,and Radix Glycyrrhizae. The control group was treated with external use of Solcoseryl Dental Adhesive Paste and oral use of small-dosage of interferon. One week constituted a course of treatment, and the treatment lasted for 2-4 courses. Before and after treatment, we observed the total amount of oral ulcers, total intermittent time for the attack of ulcers, scores of traditional Chinese medicine(TCM)symptoms, and scores of focal symptoms and signs. After treatment, the clinical efficacy and safety of the two groups were evaluated. Results(1)After treatment,the total effective rate of the observation group was 90.91%,and was higher than that of the control group(74.20%),the difference being significant(P < 0.05).(2)After treatment, the total amount of oral ulcers was reduced(P<0.05 or P<0.01)and the total intermittent time for the attack of ulcers was significantly prolonged(P < 0.01)in the two groups as compared with those before treatment, and the effects of the observation group was stronger than those of the control group(P<0.05 or P<0.01).(3)After treatment,the scores of TCM symptoms(lassitude,shortness of breath,dry mouth and thirst,scanty dark urine) and scores of focal symptoms and signs(ulcer pain,burning sensation, congestion area, ulcer a
作者 王忠武 谢婧 缪旺冬 梁淑慧 WANG Zhong-Wu;XIE Jing;MIAO Wang-Dong;LIANG Shu-Hui(People's Hospital of Longhua District, Shenzhen 518109 Guangdong, China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405 Guangdong, China)
出处 《广州中医药大学学报》 CAS 2019年第5期640-644,共5页 Journal of Guangzhou University of Traditional Chinese Medicine
基金 广东省中医药局科研立项课题(编号:2007414).
关键词 复发性口腔溃疡 中药疗法 清热化湿养阴生肌法 湿热久羁 气阴两虚 recurrent oral ulcer traditional Chinese drug therapy therapy of clearing heat and removing dampness,nourishing Yin and promoting granulation long-time retention of dampness and heat Qi-yin deficiency
作者简介 王忠武(1965-),男,中医学博士.副主任医师;E-mail:1052193199@qq.com.
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