期刊文献+

慢性阻塞性肺疾病合并肺癌患者的IL-6、IL-8与TNF-α的差异

Differences of IL-6,IL-8 and TNF-α in patients with chronic obstructive pulmonary disease and lung cancer
收藏 分享 导出
摘要 目的探究白细胞介素6(IL-6)、IL-8与肿瘤坏死因子α(TNF-α)在诱导慢性阻塞性肺疾病(COPD)致肺癌发生的作用。方法选择2015年4~10月河北省老年病医院呼吸内科收治的稳定期COPD合并肺癌患者41例作为试验组,另选取同期到院的稳定期COPD患者41例作为对照组,对比2组IL-6、IL-8、TNF-α的水平,并记录试验组不同TNM分期及是否伴有淋巴结转移者的炎性因子表达。结果试验组的IL-6、IL-8、TNF-α水平均高于对照组,(186.73±0.92)ng/L比(20.92±22.67)ng/L、(298.28±27.81)ng/L比(45.47±153.94)ng/L、(147.51±2.32)ng/L比(86.04±1.05)ng/L(P值均<0.05)。试验组TNMⅡ期IL-6、IL-8、TNF-α水平分别为(145.84±22.39)ng/L、(195.84±28.54)ng/L、(84.63±21.96)ng/L;Ⅲ期各炎性因子分别为(179.36±21.47)ng/L、(250.37±30.36)ng/L、(134.92±32.64)ng/L;Ⅳ期各炎性因子分别为(219.97±25.93)ng/L、(375.62±50.67)ng/L、(189.73±34.82)ng/L,不同分期各炎性指标比较差异均有统计学意义(P值均<0.05)。试验组伴淋巴结转移的IL-6、IL-8、TNF-α水平均高于试验组无淋巴结转移,(214.36±25.39)ng/L比(175.32±22.05)ng/L、(325.93±29.36)ng/L比(244.67±30.33)ng/L、(168.34±27.87)ng/L比(124.08±22.09)ng/L(P值均<0.05)。结论IL-6、IL-8、TNF-α可能与COPD合并肺癌的发生及发展过程有关,且COPD慢性炎症环境可促进肺癌的发生及转移。 Objective To explore the effects of interieukn (IL-6), IL-8 and tumor necrosis factor-alpha (TNF-α) on the induction of lung cancer induced by chronic obstructive pulmonary disease (COPD). Methods From April to October 2015, 41 patients with stable COPD and lung cancer admitted to the Department of Respiratory Medicine of Hebei Province Geriatrics Hospital were selected as the experimental group, and 41 patients with stable COPD at the same time were selected as the control group.The two groups were compared with IL-6 and IL-8.The level of TNF-α was recorded, and the expression of inflammatory factors in different TNM stages of the experimental group and whether or not lymph node metastasis was recorded was recorded. Results The levels of IL-6, IL-8 and TNF-α in the experimental group were (186.73±0.92) ng/L,(298.28±27.81) ng/L, and (147.51±2.32) ng/L, respectively, which were higher than those of the control group.(20.92±22.67) ng/L,(45.47±153.94) ng/L,(86.04±1.05) ng/L (P<0.05). The levels of IL-6, IL-8 and TNF-α in the TNMII phase of the experimental group were (145.84±22.39) ng/L,(195.84±28.54) ng/L,(84.63±21.96) ng/L, respectively.The factors were (179.36±21.47) ng/L,(250.37±30.36) ng/L,(134.92±32.64) ng/L;the inflammatory factors in stage Ⅳ were (219.97±25.93) ng/L, respectively (375.62±50.67) ng/L,(189.73±34.82) ng/L, the difference of inflammatory indexes in different stages was statistically significant (P<0.05). The levels of IL-6, IL-8 and TNF-α in the experimental group with lymph node metastasis were (214.36±25.39) ng/L,(325.93±29.36) ng/L,(168.34±27.87) ng/L, respectively.(175.32±22.05) ng/L,(244.67±30.33) ng/L,(124.08±22.09) ng/L (P<0.05). Conclusions IL-6, IL-8 and TNF-α may be involved in the occurrence and development of lung cancer with COPD, and the chronic inflammatory environment of COPD can promote the occurrence and metastasis of lung cancer.
作者 李林 杨智晖 刘青 梁瑞凯 梁瑞景 冯海利 侯亮 林飞刚 Li Lin;Yang Zhihui;Liu Qing;Liang Ruikai;Liang Ruijing;Feng Haili;Hou Liang;Lin Feigang(Department of Respiratory Medicine,Hebei Provincial Geriatric Hospital,Shijiazhuang 050011,China;Department of Pathology,First People′s Hospital of Wu′an,Wu′an 056300,China)
出处 《国际呼吸杂志》 2019年第9期668-671,共4页 International Journal of Respiration
关键词 白细胞介素6 白细胞介素8 肿瘤坏死因子Α 肺疾病 慢性阻塞性 肺肿瘤 Interleukin-6 Interleukin-8 Tumor necrosis factor-alpha Pulmonary disease, chronic obstructive Lung neoplasms
作者简介 通信作者:杨智晖,Email:569509007@qq.com.
  • 相关文献
投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈