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瑞舒伐他汀对兔急性心肌梗死后心肌重构的作用及功能影响的机制研究 预览

Function and mechanism of rosuvastatin on myocardial remodeling in rabbits with acute myocardial infarction
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摘要 目的研究瑞舒伐他汀对兔急性心肌梗死(AMI)后心肌重构的作用及功能影响的机制。方法选择80只大白兔建立AMI模型,将存活的69只大白兔分为对照组(MI组,n=20)、瑞伐他汀组(R组,n=22)、假手术组(S组,n=27)。S组仅穿线不结扎冠状动脉,R组灌胃给予瑞舒伐他汀钙,MI组建立AMI后不予任何操作,观察各组心脏超声心动图情况,比较各组心肌梗死面积、细胞凋亡率、心肌梗死边缘区Caspase-3、p-p38蛋白和p38的表达。结果 3组间超声心动图指标比较,差异有统计学意义(P<0.05);与S组相比,MI组与R组的左心房直径(LAD)、左心室舒张末期内径(LVDd)和左心室收缩末期内径(LVDs)均显著增加,同时左心室射血分数(LVEF)和左心室短轴缩短率(LVFS)降低(P<0.05);R组LAD、LVDd和LVDs与MI组比较差异无统计学意义(P>0.05),LVEF和LVFS高于MI组(P<0.05)。S组心肌梗死面积为0,MI组与R组间比较差异无统计学意义(P>0.05)。MI组[(24.42±2.52)%]和R组[(9.31±0.31)%]凋亡指数(AI)显著高于S组[(2.65±0.32)%](P<0.05),R组AI较MI组显著降低(P<0.05);R组及MI组心肌梗死边缘区Caspase-3表达较S组明显升高,而R组较MI组显著降低(P<0.05);MI组、R组、S组p38表达均未见明显差异,MI组和R组p-p38表达较S组明显升高,而R组较MI组显著降低(P<0.05)。结论瑞舒伐他汀可以使AMI大白兔的心脏功能显著改善,可能通过抑制p38的磷酸化,抑制Caspase-3活化,抑制心肌细胞凋亡,改善心室重构。 Objective To discuss the effect of rosuvastatin on myocardial remodeling in rabbits with acute myocardial infarction and its pathogenetic mechanism.Methods 80 healthy rabbits were established for AMI model by left anterior descending coronary artery.The survived 69 rabbits were divided into three groups:the control group(group MI,n=20),the rosuvastatin group(group R,n=22)and the sham group(group S,n=27).Only threading with no ligation at coronary artery was conducted in group S.The rabbits in group R were given rosuvastatin calcium.Group MI didnt receive any operations.Cardiac echocardiography was adopted by using color doppler ultrasonography.Comparisons in area of myocardial infaraction,apoptsis index(AI),expression of Caspase-3 p-p38 protein and p-p38 in marginal,were made between groups.Results There were significant difference between related indexes of echocardiogram in the three groups(P<0.05).Compared with group S,left atrial diameter(LAD),left ventricular diastolic diameter(LVDd)and left ventricular systolic diameter(LVDs)all increased significantly with the reduction of LVEF and LVFS in group MI and R(P<0.05).There was no significant difference in LVDs,LVDd and LAD between group R and MI(P>0.05)and LVEF and LVFS were higher than those in group MI(P<0.05).The area of myocardial infarction in group S was 0,and there was no significant difference between group MI and R(P>0.05).The AI in group MI[(24.42±2.52)%]and R [(9.31±0.31)%]was significantly higher than that in group S[(2.65±0.32)%](P<0.05).AI in group R was significantly lower than that in group MI(P<0.05).Caspase-3 expression in the marginal area of myocardial infarction in group R and MI was significantly higher than that in group S,while that in group R was significantly lower than that in group MI(P<0.05).P38 expression in group MI,R and S was not significantly different.P-p38 expression in group MI and R was significantly higher than that in group S,while that in group R was significantly lower than that in group MI(P<0.05).Conclusion Rosuvas
作者 武鑫玲 姜娟 WU Xinling;JIANG Juan(Department of Vasculocardiology,Zhengzhou People's Hospital,Zhengzhou,Henan 450053,China;Department of Geriatric Medicine,People's Hospital of Peking University,Beijing 100044,China)
出处 《重庆医学》 CAS 2019年第10期1635-1638,共4页 Chongqing medicine
基金 国家自然科学基金项目(81471203)。
关键词 心肌梗死 心室重构 基质金属蛋白酶类 转化生长因子Β1 瑞舒伐他汀 myocardial infarction ventricular remodeling matrix metalloproteinases transforming growth factor beta1 rosuvastatin
作者简介 武鑫玲(1981-),主治医师,硕士,主要从事冠心病、心力衰竭、高脂血症、高血压等心内科常见病多发病的诊治工作。
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