Objective To analyze the application effect of the whole-course nursing intervention mode in the treatment of asthma in children. Methods Thirty-six children with pediatric asthma admitted to our hospital from June 2015 to August 2016 were randomly divided into two groups. The control group received routine nursing care. The observation group implemented full-course nursing intervention to compare the effects of the two groups. Results After taking different nursing measures, the total effective rate of observation group(94.44%) was significantly higher than that of the control group(77.78%), the difference was statistically significant(χ^2=11.840, P<0.05), forced expiratory volume in the first second. of(FEV1)(t=9.104) and peak expiratory flow rate(PEF)(t=12.370) were significantly higher than the control group. The difference between the two groups was statistically significant(P<0.05). Conclusion The implementation of full-course nursing intervention in the process of asthma in children can significantly improve the therapeutic effect and improve lung function, which is worthy of clinical application and promotion.