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TACE治疗胰腺神经内分泌肿瘤肝转移的疗效分析 预览

TACE for the treatment of hepatic metastases from pancreatic neuroendocrine tumors: evaluation of its curative effect
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摘要 目的评估肝动脉化疗栓塞(TACE)治疗胰腺神经内分泌肿瘤(PNET)肝转移的疗效。方法回顾性收集经手术或穿刺病理证实的25例PNET肝转移行TACE治疗的患者资料,共进行了87次TACE术。经MRI评价其有效率,并分析无进展生存期(PFS)、总生存期(OS)和并发症。结果所有25例患者均顺利完成介入治疗。MRI疗效评估结果为CR 0例,PR 15例,SD 4例,PD 6例,有效率60.0%;中位PFS 13个月,中位OS 18个月;1例术中出现假性动脉瘤,所有病例术后均无严重并发症。结论对于不能手术切除的PNET肝转移患者,行TACE治疗既安全又能获得较好的临床疗效。 Objective To evaluate the curative efficacy of transcatheter arterial chemoembolization(TACE) in the treatment of hepatic metastases from pancreatic neuroendocrine tumors(PNET). Methods The clinical data of 25 patients with surgically or pathologically proved hepatic metastases from PNET, who received TACE, were retrospectively analyzed. A total of 87 TACE procedures were performed. The effective rate was evaluated by MRI, and the progression-free survival time(PFS), overall survival time(OS) and complications were analyzed. Results The interventional therapy was successfully accomplished in all the 25 patients. The MRI evaluation of the curative effect showed that complete remission(CR) was obtained in 0 patient, partial remission(PR) in 15 patients, stable disease(SD) in 4 patients, and progression disease(PD)in 6 patients. The total effective rate was 60%. The median PFS was 13 months and the median OS was 18 months. No serious complications occurred in all patients except for one patient who developed pseudoaneurysm during operation. Conclusion For the treatment of patients with inoperable hepatic metastases from PNET, TACE is safe and effective.
作者 马建兵 杨朝爱 江旭 刘航 罗荣 吴林霖 杨继金 孙军辉 MA Jianbing;YANG Chaoai;JIANG Xu;LIU Hang;LUO Rong;WU Linlin;YANG Jijin;SUN Junhui(Hepatobiliary and Pancreatic Intervention Center, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China)
出处 《介入放射学杂志》 CSCD 北大核心 2019年第5期468-471,共4页 Journal of Interventional Radiology
关键词 胰腺 神经内分泌肿瘤 肝转移 肝动脉化疗栓塞 pancreas neuroendocrine tumor hepatic metastasis transcatheter arterial chemoembolization
作者简介 通信作者:孙军辉,E-mail: 1307005@zju.edu.cn.
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