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中性粒细胞与淋巴细胞比值预测急性胰腺炎严重程度的临床价值 预览

Clinical value of the ratio of neutrophils to lymphocytes in predicting the severity of acute pancreatitis
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摘要 目的探讨外周血中性粒细胞与淋巴细胞比值(NLR)预测急性胰腺炎(AP)严重程度的价值。方法回顾性分析2015年1月~2017年6月就诊于海军军医大学附属长征医院的114例AP患者的临床资料,选取94名健康志愿者为对照组,114例为AP组。比较两组间血常规、肝肾功能、电解质的指标变化;根据亚特兰大新分类标准,将AP组患者分为轻度(MAP)、中度(MSAP)和重度(SAP)三组,比较三组间NLR、血肌酐及钙离子水平差异;采用Spearman秩相关比较NLR与血肌酐及钙离子水平间的相关性,进一步通过受试者工作特征(ROC)曲线比较NLR、血肌酐、钙离子对SAP的诊断价值。结果与对照组比较,AP组NLR、血肌酐明显升高(均P<0.05)。NLR与AP的严重程度明显相关(P<0.05),与血肌酐呈正相关(r=0.191,P<0.05),与钙离子呈负相关(r=-0.244,P<0.01)。NLR诊断SAP的曲线下的面积为0.81(95%CI:0.703~0.924),与血肌酐、钙离子比较,差异无统计学意义(均P>0.05)。结论 NLR对预测AP的严重程度具有一定的临床意义。 Objective To investigate the value of peripheral blood neutrophil/lymphocyte ratio (NLR) in predicting the severity of acute pancreatitis (AP). Methods A retrospective analysis was performed on the clinical data of 114 AP patients admitted to the Changzheng Hospital Affiliated to the Second Military Medical University from January 2015 to June 2017, 94 healthy volunteers were selected as the control group and 114 patients as the AP group. Blood routine, liver and kidney function, and electrolyte indexes were compared between the two groups. According to the new classification standard of Atlanta, AP patients were divided into three groups, mild (MAP), moderate (MSAP) and severe (SAP). Spearman rank correlation was used to compare the correlation between NLR and serum creatinine and calcium ion level, and the diagnostic value of NLR, serum creatinine and calcium ion in SAP was further compared by ROC curve. Results Compared with healthy control group, NLR and serum creatinine were significantly increased in AP group (all P<0.05). There was a correlation between NLR and AP severity (P<0.05), positive correlation with serum creatinine (r = 0.191, P<0.05), and negatively correlated with calcium ions (r =-0.244, P<0.01). The area under the curve of NLR diagnosis of SAP was 0.81 (95%CI: 0.703-0.924), and the difference was not statistically significant compared with serum creatinine and calcium ions (all P > 0.05). Conclusion NLR has certain clinical significance in predicting the severity of AP.
作者 刘魏 卢红娟 孔乐乐 樊笑霞 仲人前 周琳 LIU Wei;LU Hongjuan;KONG Lele;FAN Xiaoxia;ZHONG Renqian;ZHOU Lin(Department of Laboratory Diagnostics, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China;Department of Rheumatology, Changzheng Hospital Affiliated to the Second Military Medical University, Shanghai 200003, China)
出处 《中国医药导报》 CAS 2019年第13期159-162,共4页 China Medical Herald
基金 国家自然科学基金资助项目(31500716)。
关键词 急性胰腺炎 中性粒细胞与淋巴细胞比值 严重程度 临床价值 Acute pancreatitis Neutrophil-lymphocyte ratio Severity Clinical significance
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