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2型糖尿病伴慢性心力衰竭患者心电图Q-T间期离散度与心脏不良事件的关系研究 预览

Relationship between Q-T interval dispersion on electrocardiogram and adverse cardiac events in patients with type 2 diabetes mellitus and chronic heart failure
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摘要 目的研究2型糖尿病伴慢性心力衰竭患者心电图Q-T间期离散度(QTd)与心脏不良事件的关系。方法以2016年2月~2017年12月河北省衡水市哈励逊国际和平医院收治的2型糖尿病伴慢性心力衰竭患者200例为研究对象。对所有患者进行为期6个月的随访,根据患者是否发生心脏不良事件分为心脏不良事件组(63例)以及无心脏不良事件组(137例)。分别比较两组一般资料、各项生化指标水平、超声心动图指标水平,并作多因素Logistic回归分析。结果心脏不良事件组尿酸(UA)、QTd、校正Q-T间期离散度(QTcd)水平均高于无心脏不良事件组(P<0.05)。心脏不良事件组左室射血分数(LVEF)水平低于无心脏不良事件组(P<0.05)。经多因素Logistic回归分析可得:UA、QTd、QTcd均是2型糖尿病伴慢性心力衰竭患者发生心脏不良事件的独立危险因素(P<0.05),而LVEF是保护性因素(P<0.05)。结论2型糖尿病伴慢性心力衰竭患者心电图QTd与QTcd增大均增加了其心脏不良事件发生的风险,值得临床重点关注。 Objective To study the relationship between Q-T interval dispersion(QTd)on electrocardiogram and adverse cardiac events in patients with type 2 diabetes mellitus and chronic heart failure.Methods Two hundred patients with type 2 diabetes mellitus and chronic heart failure admitted to Hengshui Harrison International Peace Hospital in Hebei Province from February 2016 to December 2017 were selected as the subjects.All patients were followed up for 6 months,and they were divided into adverse cardiac events group(n=63)and non-adverse cardiac events group(n=137)according to whether the patient had adverse cardiac events.The basic data,the level of biochemical index and echocardiographic index of the two groups were compared,and multivariate Logistic regression analysis was performed.Results The level of uric acid(UA),QTd and corrected QTd(QTcd)in the adverse cardiac events group was higher than that in the non-adverse cardiac events group(P<0.05).The left ventricular ejection fraction(LVEF)level in the adverse cardiac events group was lower than that in the non-adverse cardiac events group(P<0.05).The multiple Logistic regression analysis showed that UA,QTd and QTcd were independent risk factors for the occurrence of adverse cardiac events in patients with type 2 diabetes mellitus and chronic heart failure(P<0.05),while LVEF was a protective factor(P<0.05).Conclusion The increase of QTd and QTcd in electrocardiogram in patients with type 2 diabetes mellitus and chronic heart failure increases the risk of adverse cardiac events,which is worthy of clinical attention.
作者 刘娟 苏兵 李硕 王薇 沈林 王亚娟 LIU Juan;SU Bing;LI Shuo;WANG Wei;SHEN Lin;WANG Yajuan(Department of Clinical Electrophysiology,Harrison International Peace Hospital,Hebei Province,Hengshui 053000,China)
出处 《中国医药导报》 CAS 2019年第14期56-59,共4页 China Medical Herald
基金 河北省衡水市科技计划项目(15020)。
关键词 2型糖尿病 慢性心力衰竭 Q-T间期离散度 多因素LOGISTIC回归分析 Type 2 diabetes mellitus Chronic heart failure Q-T interval dispersion Multiple Logistic regression analysis
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