Objective It is to investigate the expression of PTEN, PAX-2 and EMP2 in endometrial hyperplasia, and to explore its relationship with endometrial hyperplasia and its clinical significance. Methods Immunohistochemistry was used to detect the expression of PTEN, PAX-2 and EMP2 proteins in endometrial tissue of endometrial hyperplasia without atypical hyperplasia(benign hyperplasia), endometrial atypical hyperplasia/endometrial intraepithelial neoplasia (EIN), and normal proliferative endometrial tissues. Results In the endometrial hyperplasia, the expression of PTEN and PAX-2 was significantly decreased or absent, the difference was statistically significant compared with the normal proliferative endometrium ( P <0.05). The expression of EMP2 was significantly enhanced in endometrial hyperplasia, the difference was statistically significant compared with the normal proliferative endometrium ( P <0.05). Conclusion The abnormal expression of PTEN, PAX-2 and EMP2 is associated with the occurrence of endometrial hyperplasia, and it has certain auxiliary significance for the diagnosis of endometrial hyperplasia.
Modern Journal of Integrated Chinese Traditional and Western Medicine