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布托啡诺与芬太尼应用于宫腔镜手术对患者自主呼吸的影响 预览

Effects of butorphanol and fentanyl on spontaneous breathing in patients undergoing hysteroscopic surgery
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摘要 目的 比较布托啡诺和芬太尼分别联合丙泊酚用于宫腔镜手术患者对自主呼吸的影响。方法 选择2018年3月—2018年6月在本中心拟行宫腔镜检查术的患者100例,随机分为B组和F组,每组50例。B组静脉注射布托啡诺20μg/kg,F组静脉注射芬太尼1μg/kg,两组均于3min后静脉注射丙泊酚2.0mg/kg。术中根据患者反应追加丙泊酚。记录B、F两组患者给药前(T0)、静注完毕丙泊酚后1min(T1)、3min(T2)、5min(T3)、8min(T4)各个时间点的呼吸频率(RR)、脉搏血氧饱和度(SpO2),低SpO2(85%≤SpO2<90%)持续时间,及两组术中SpO2下降至84%时需要面罩辅助加压给氧的患者例数。结果 两组患者在T0、T1、T3及T4时间点的RR、SpO2均在正常范围内,差异无统计学意义(P>0.05);在T2时间点,与F组比较,B组患者的RR和SpO2明显升高(P<0.05)。B组患者术中低SpO2(85%≤SpO2<90%)持续时间明显短于F组(P<0.05);B组需面罩辅助加压给氧的患者例数为1例(2.00%)明显少于F组11例(22.00%)(P<0.05)。结论 布托啡诺联合丙泊酚用于宫腔镜手术麻醉,相比于芬太尼,具有较轻的呼吸抑制作用及减少麻醉者工作量的优势。 Objective To compare the effects of butorphanol combined with propofol and fentanyl combined with propofol on spontaneous breathing in patients undergoing hysteroscopic surgery.Methods A total of 100 patients who planned to receive hysteroscopy in our center from March 2018 to June 2018 were selected and randomly divided into group B(n=50)and group F(n=50).Patients in group B received intravenous injection of butorphanol 20μg/kg,while patients in group F received intravenous injection of fentanyl 1μg/kg,both groups received intravenous injection of propofol 2.0 mg/kg after 3 minutes.Propofol was added according to the patient’s reaction during the operation.The respiratory rate(RR)and pulse oxygen saturation(SpO 2),the duration of low SpO 2(85%≤SpO 2<90%)and the number of patients requiring mask-assisted pressure oxygen supply when SpO 2 decreased to 84%in both groups were recorded at five time points:before drug administration(T0),and at 1 min(T1),3 min(T2),5 min(T3)and 8 min(T4)after intravenous propofol administration.Results RR and SpO 2 of both groups at T0,T1,T3 and T4 time points were within normal range,and the difference was not statistically significant(P>0.05).RR and SpO 2 were significantly increased at T2 in group B compared with group F(P<0.05).The duration of low SpO 2(85%≤SpO 2<90%)in group B was significantly shorter than that in group F(P<0.05),and the number of patients in group B who needed mask-assisted pressurization for oxygen supply was 1(2.00%)which was significantly less than that in group F(11 patients,22.00%)(P<0.05).Conclusion Compared with fentanyl,butorphanol combined with propofol has the advantages of less respiratory depression and less workload for anesthesiologists in hysteroscopic anesthesia.
作者 彭镌宝 苏高盛 饶杰 刘波 Peng Juanbao;Su Gaosheng;Rao Jie;Liu Bo(The Guangxi Zhuang Autonomous Region Family Planning ResearchCenter,Nanning 530021,Guangxi,China)
出处 《右江民族医学院学报》 2019年第3期320-323,共4页 Journal of Youjiang Medical College For Nationalities
关键词 宫腔镜 布托啡诺 芬太尼 丙泊酚 自主呼吸 hysteroscopy butorphanol fentanyl propofol spontaneous breathing
作者简介 第一作者:彭镌宝(1983-),男,硕士,主治医师,研究方向:临床麻醉与术后认知功能障碍,E-mail:278801896@qq.com.
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