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SDF-1、CXCR4在丙肝肝硬化患者外周血中的表达及其临床意义

Expression and clinical significance of SDF-1 and CXCR4 in peripheral blood of patients with hepatitis C cirrhosis
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摘要 目的检测基质细胞衍生因子1(SDF-1)、趋化因子受体4(CXCR4)在丙肝肝硬化患者外周血中的表达情况及其临床意义。方法选取2015年1月至2018年1月在本院感染科就诊的120例丙肝肝硬化患者为研究对象,其中丙肝代偿期和失代偿期的肝硬化患者各60例,以同时期丙肝无肝硬化患者60例作为对照组。采用酶联免疫吸附(ELISA)法检测血清中SDF-1、CXCR4的表达量;分析SDF-1、CXCR4在代偿期和失代偿期的肝硬化患者表达的相关性,利用多元回归分析,判断丙肝肝硬化的危险因素。结果丙肝失代偿期肝硬化患者外周血样本SDF-1、CXCR4表达水平明显高于代偿期肝硬化患者(P<0.05);丙肝代偿期和失代偿期肝硬化患者外周血样本SDF-1、CXCR4表达水平明显高于对照组(P<0.05);代偿期和失代偿期肝硬化患者外周血中SDF-1与CXCR4的表达均呈正相关(r=0.684,P<0.01;r=0.765,P<0.01)。肝硬化组患者外周血中AlB水平明显低于对照组(P<0.05),ALT、AST、TBIL、FINs、IL-6水平均高于对照组(P<0.05)。丙肝肝硬化组患者外周血中SDF-1、CXCR4水平与FINs、IL-6均呈正相关(P<0.05);多元回归分析显示,FINs、IL-6、SDF-1、CXCR4是导致丙肝肝硬化的危险因素。结论丙肝肝硬化患者外周血SDF-1、CXCR4升高,其外周血中SDF-1与CXCR4水平呈明显正相关,提示二者可能参与调控丙肝肝硬化的发生、发展。 Objective To detect the expression and clinical significance of stro-mal cell derived factor-1 (SDF-1) and CXC chemokine receptor 4 (CXCR4) in peripheral blood of patients with hepatitis C cirrhosis. Methods From January 2015 to January 2018, 120 patients with hepatitis C cirrhosis in our hospital were selected as the subjects, including 60 patients with compensated hepatitis C cirrhosis and 60 patients with decompensated hepatitis C cirrhosis, and 60 hepatitis C patients without cirrhosis in the same period were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of SDF-1 and CXCR4 in peripheral blood;the correlation between SDF-1 and CXCR4 expressions in compensated cirrhosis and decompensated cirrhosis patients was analyzed. Results The expression levels of SDF-1 and CXCR4 in peripheral blood samples of patients with decompensated cirrhosis of hepatitis C were significantly higher than those of patients with compensated cirrhosis of hepatitis C (P<0.05);the expression levels of SDF-1 and CXCR4 in peripheral blood samples of patients with compensated and decompensated cirrhosis of hepatitis C were significantly higher than those of control group (P<0.05);the expressions of SDF-1 and CXCR4 in peripheral blood of patients with compensated and decompensated cirrhosis of hepatitis C were positively correlated (r=0.684, P<0.05, r=0.765, P<0.05). Albumin (AlB) level in peripheral blood of cirrhosis group was significantly lower than that of control group (P<0.05);alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), while fasting insulin (FINs) and interleukin (IL)-6 in cirrhosis group were higher than those of control group (P<0.05);SDF-1 level and CXCR4 level were positively correlated with AlB, FINs and IL-6 (P<0.05);multiple regression analysis showed that FINs, IL-6, SDF-1 and CXCR4 were risk factors for hepatitis C cirrhosis. Conclusions The levels of SDF-1 and CXCR4 in peripheral blood of patients with hepatitis C
作者 李劲 钟慧筠 黎绍球 陈刘镇 Li Jin;Zhong Huiyun;Li Shaoqiu;Chen Liuzhen(Department of Infectious Diseases, the People′s Hospital of Dongguan, Dongguan 523000, China;Department of General Surgery, the People′s Hospital of Dongguan, Dongguan 523000, China)
出处 《中国医师杂志》 CAS 2019年第5期723-726,共4页 Journal of Chinese Physician
关键词 趋化因子CXCL12 受体 CXCR4 丙型肝炎 肝硬化 Chemokine CXCL12 Receptors, CXCR4 Hepatitis C Liver cirrhosis
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