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Understanding the importance of autophagy in human diseases using Drosophila

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摘要 Autophagy is a lysosome-dependent intracellular degradation pathway that has been implicated in the pathogenesis of various human diseases, either positively or negatively impacting disease outcomes depending on the specific context. The majority of medical conditions including cancer, neurodegenerative diseases, infections and immune system disorders and inflammatory bowel disease could probably benefit from therapeutic modulation of the autophagy machinery. Drosophila represents an excellent model animal to study disease mechanisms thanks to its sophisticated genetic toolkit, and the conservation of human disease genes and autophagic processes. Here, we provide an overview of the various autophagy pathways observed both in flies and human cells(macroautophagy, microautophagy and chaperone-mediated autophagy), and discuss Drosophila models of the above-mentioned diseases where fly research has already helped to understand how defects in autophagy genes and pathways contribute to the relevant pathomechanisms.
出处 《遗传学报:英文版》 SCIE CAS CSCD 2019年第4期157-169,共13页 Journal of Genetics and Genomics
基金 the Hungarian Academy of Sciences (LP-2014/2) the National Research Development and Innovation Office (GINOP-2.3.2-152016-00006 and -00032, and K119842) supported by the UNKP-18-4 New National Excellence Program of the Ministry of Human Capacities the János Bolyai Research Fellowship of the Hungarian Academy of Sciences supported by a National Research, Development and Innovation Office fellowship (PD128280).
作者简介 Corresponding author:Gabor Juhasz,E-mail address:szmrt@elte.hu.
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