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AGEs对冠心病合并糖尿病患者细胞内胆固醇外流通路的影响及作用机制 预览

Effect of AGEs on intracellular cholesterol efflux pathway in patients with coronary heart disease complicated with diabetes mellitus and its mechanism
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摘要 目的探讨AGEs对冠心病合并糖尿病患者细胞内胆固醇外流通路的影响及作用机制。方法选取2013年8月~2015年10月我院诊治的75例冠心病合并糖尿病的患者将其作为研究组,选取同时期在我院进行体检的健康人员75例作为对照组。研究糖基化终末产物(advanced glycosylation end products,AGEs)对冠心病合并糖尿病患者细胞内胆固醇外流通路的影响,对比两组患者的糖基化终末产物(AGEs)水平以及胆固醇外流率的大小。结果研究组患者AGEs水平明显高于对照组,差异有统计学意义(P<0.05)。研究组患者的胆固醇的外流率明显低于对照组,差异有统计学意义(P<0.05)。HDL-C经由ABCA1途径的胆固醇流出在对照组和研究组均与PLTP活性成正相关。结论冠心病合并糖尿病患者血清组织内的AGEs含量水平会大幅度上升,同时AGEs含量的积累会导致细胞内胆固醇外流通路受到阻碍,胆固醇外流率降低,因此,AGEs在冠心病合并糖尿病的发生发展中起到重要作用。 Objective To investigate the effect of AGEs on intracellular cholesterol efflux pathway in patients with coronary heart disease and diabetes mellitus and its mechanism.Methods A total of 75 patients with coronary heart disease and diabetes admitted in our hospital from August 2013 to October 2015 were enrolled as the study group.75 healthy people who underwent physical examination in our hospital were selected as the control group.The effects of advanced glycosylation end products(AGEs)on intracellular cholesterol efflux pathway in patients with coronary heart disease and diabetes were studied.And the levels of advanced glycosylation end products(AGEs)and cholesterol efflux between the two groups were compared.Results The AGEs level in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The efflux rate of cholesterol in the study group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).The cholesterol efflux of HDL-C via the ABCA1 pathway was positively correlated with PLTP activity in both the control and study groups,respectively.Conclusion The level of AGEs in serum tissue of patients with coronary heart disease and diabetes mellitus will increase significantly.At the same time,the accumulation of AGEs will lead to the obstruction of intracellular cholesterol efflux pathway and the decrease of cholesterol efflux rate.Therefore,the AGEs play an important role in the development of coronary heart disease and diabetes.
作者 徐海鹰 钟益刚 杨俊 周占林 王宁夫 许轶洲 XU Haiying;ZHONG Yigang;YANG Jun;ZHOU Zhanlin;WANG Ningfu;XU Yizhou(Department of Cardiology,Hangzhou First People's Hospital Affiliated to Zhejiang University School of Medicine,Hangzhou 310006,China)
出处 《中国现代医生》 2019年第14期44-47,共4页
基金 浙江省杭州市科技发展计划项目(20130733Q06).
关键词 糖基化终末产物 冠心病 糖尿病 胆固醇外流通路 Advanced glycosylation end products Coronary heart disease Diabetes Cholesterol efflux pathway
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