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双相障碍与甲状腺功能异常的研究进展 预览

Progress in Study of Bipolar Disorder and Thyroid Function Abnormality
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摘要 双相障碍(BD)是一种常见的精神疾病,以情感异常高涨或低落为主要表现。其确切病因目前尚不清楚,可能与遗传因素、家庭环境、生活事件有关。近年来,甲状腺与BD的关系受到国内外学者的广泛重视,下丘脑-垂体-甲状腺轴功能失调、甲状腺自身免疫性疾病均可能与BD有一定关联,且BD患者部分心境稳定剂(碳酸锂)的长期使用也可能对其甲状腺功能产生一定影响。另外,甲状腺功能与BD之间可能存在潜在的神经生物学机制。因此,两者之间的关系比较复杂,未来需进一步研究。 Bipolar disorder(BD) is a common mental disorder characterized by abnormal emotional ups and downs.The exact etiology is not clear at present,which may be related to genetic factors, family environment and life events.In recent years,the relationship between thyroid and BD has attracted extensive attention from scholars at home and abroad.Hypothalamic-pituitary-thyroid axis dysfunction and thyroid autoimmune diseases may be related to BD,and long-term use of some mood stabilizers(lithium carbonate) in BD patients may also affect thyroid function.In addition, there may be potential neurobiological mechanisms between thyroid function and BD.Therefore,the relationship between the two is complex and needs further study in the future.
作者 刘瑞 陈俊 方贻儒 LIU Rui;CHEN Jun;FANG Yiru(Mental Health Center Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences Institute of Neuroscience,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 200031,China;Shanghai Key Laboratory of Severe Psychiatry,Shanghai 200030,China)
出处 《医学综述》 2019年第11期2086-2091,共6页 Medical Recapitulate
基金 国家自然科学基金(91232719,81201056,81761128032) 国家重点研发计划重大慢性非传染性疾病防控研究重点专项(2016YFC1307100) 促进市级医院临床技能与临床创新三年行动计划(16CR2027B) 国家临床重点专科建设(卫办医政函〔2011〕873号) 上海市科学技术委员会科研计划项目(12401906200).
关键词 双相障碍 甲状腺功能异常 下丘脑-垂体-甲状腺轴 碳酸锂 Bipolar disorder Thyroid function abnormality Hypothalamic-pituitary-thyroid axis Lithium carbonate
作者简介 通信作者:陈俊, E-mail:doctorcj2010@gmail.com;通信作者:方贻儒,yirufang@aliyun.com.
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