Objective: To study the hypolipidemic effect of Panax notoginsenosidum on golden hamsters with hyperlipidemia. Methods: The golden hamsters were fed with high fat diet for 4 weeks to establish a hyperlipidemia animal models, and were randomly divided into normal group, hyperlipidemia model group, Xuesaitong group. After 12 weeks, the contents of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) in serum were detected;the activity of superoxide dismutase (SOD), the contents of malondialdehyde (MDA) and free fatty acid (NEFA) in serum was detected. The hepatic pathological changes were observed by HE staining. Results: Compared with the normal control group, the content of TC, TG and LDL-C in the serum of the model group increased significantly. After treatment, compared with the model group, the content of TC, TG, LDL-C, MDA and NEFA in the treatment group decreased significantly, and the activity of SOD was not significantly different from that in the model group. HE staining showed that hepatocytes in the model group were swollen, necrotic and infiltrated with inflammatory cells, which were improved after treatment. Conclusion: Panax notoginsenosidum can reduce the level of blood lipid in hyperlipidemic hamsters, and has the effect of protecting liver, which may be related to enhancing the anti-lipid oxidation ability of the body.
Journal of Hebei Traditional Chinese Medicine and Pharmacology
Deficiency of liver and kidney
Qistagnation and blood stasis