期刊文献+

三七总皂苷对高脂血症金黄地鼠降脂作用的研究 预览

Hypolipidemic Effect of Panax Notoginsenosidum on Golden Hamsters with Hyperlipidemia
在线阅读 下载PDF
分享 导出
摘要 目的:研究三七总皂苷对高脂血症金黄地鼠的降血脂作用。方法:采用金黄地鼠给予高脂饲料4周建立高血脂动物模型,随机分为正常组,高血脂模型组,血塞通组,12周后:检测血清中总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C),低密度脂蛋白胆固醇(LDL-C)的含量;检测血清超氧化物歧化酶(SOD)活性及丙二醛(MDA)和游离脂肪酸(NEFA)的含量;HE染色观察肝脏的病理学变化。结果:与正常对照组相比,模型组金黄地鼠血清TC、TG、LDL-C含量显著升高,经过给药治疗后,与模型组相比,治疗组TC、TG、LDL-C、MDA、NEFA含量显著下降,SOD活性与模型组相比并未显著差异。肝脏组织HE染色显示,模型组肝细胞肿胀、坏死,有炎性细胞浸润,经给药治疗后有所好转。结论:三七总皂苷可降低高血脂地鼠的血脂水平,具有保肝功效,可能与其增强肌体抗脂质氧化能力有关。 Objective: To study the hypolipidemic effect of Panax notoginsenosidum on golden hamsters with hyperlipidemia. Methods: The golden hamsters were fed with high fat diet for 4 weeks to establish a hyperlipidemia animal models, and were randomly divided into normal group, hyperlipidemia model group, Xuesaitong group. After 12 weeks, the contents of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) in serum were detected;the activity of superoxide dismutase (SOD), the contents of malondialdehyde (MDA) and free fatty acid (NEFA) in serum was detected. The hepatic pathological changes were observed by HE staining. Results: Compared with the normal control group, the content of TC, TG and LDL-C in the serum of the model group increased significantly. After treatment, compared with the model group, the content of TC, TG, LDL-C, MDA and NEFA in the treatment group decreased significantly, and the activity of SOD was not significantly different from that in the model group. HE staining showed that hepatocytes in the model group were swollen, necrotic and infiltrated with inflammatory cells, which were improved after treatment. Conclusion: Panax notoginsenosidum can reduce the level of blood lipid in hyperlipidemic hamsters, and has the effect of protecting liver, which may be related to enhancing the anti-lipid oxidation ability of the body.
作者 吴江立 安胜军 安然 常宏 WU Jiang-li;AN Sheng-jun;AN Ran;CHANG Hong(Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Hebei University of Chinese Medicine,Shijiazhuang 050091)
出处 《河北中医药学报》 2019年第3期5-7,15共4页 Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金 河北省教育厅基金资助项目:No.Z2017075 河北省教育厅基金项目:No.ZD2016034 河北中医学院博士科研基金:No.BSZ2016003.
关键词 三七总皂苷 高脂血症 金黄地鼠 血塞通 肝肾亏虚 气滞血瘀 眩晕 胸痹 Panax notoginsenosidum Hyperlipidemia Goldenhamster Xuesaitong Deficiency of liver and kidney Qistagnation and blood stasis Vertigo Chest impediment
作者简介 通讯作者:常宏,女,博士,教授。
  • 相关文献

参考文献5

二级参考文献102

共引文献94

投稿分析

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部 意见反馈