目的 探讨脑血管病危险因素对帕金森病(PD)患者颈动脉斑块形成的影响及斑块形成数量与各因素的相关性。方法 选取2016—2018年在河南省人民医院住院的79例PD患者,通过颈动脉彩超分为斑块组和非斑块组,记录颈动脉斑块形成数量。2组均登记详细病史,测空腹尿酸、血脂、同型半胱氨酸(Hcy)、胱抑素C、叶酸、维生素B12,并进行比较。结果 斑块组年龄、起病年龄、糖尿病发生率、Hcy含量均大于非斑块组,斑块组左旋多巴等效剂量(LED)较非斑块组低,差异均有统计学意义(P<0.05);Spearman相关分析显示,颈动脉斑块形成的数量与总胆固醇、随机葡萄糖水平呈正相关(P<0.05)。结论 年龄大、起病晚、Hcy增高、有糖尿病史的PD患者更易形成颈动脉斑块,胆固醇、随机葡萄糖水平可影响斑块形成的数量。
Objective To investigate the effect of cerebrovascular risk factors on carotid artery plaque formation in patients with Parkinson's disease (PD) and the correlation between the number of plaque formation and various factors. Methods 79 PD patients hospitalized in our hospital from 2016 to 2018 were selected.Carotid artery ultrasound was used to divide the patients into two groups (plaque group and non plaque group),and the number of carotid artery plaque formation was recorded.Detailed medical histories were recorded in both groups,Fasting uric acid,blood fat,triglyceride,homocysteine (Hcy),cystatin C,folic acid,vitamin B12 were measured and compared between the two groups. Results Age of plaque group,age of onset,incidence of diabetes and Hcy content in plaque group were all higher than those in non plaque group.Levodopa equivalent dose (LED) in plaque group was lower than that in non plaque group,and the difference was statistically significant ( P <0.05).Spearman correlation analysis showed that the number of carotid plaque formation was positively correlated with cholesterol and random glucose content( P <0.05). Conclusion PD patients with older age,late onset,Increased Hcy and a history of diabetes are more likely to form carotid artery plaques.Cholesterol and random glucose levels can affect the number of plaques.
Chinese Journal of Practical Neruous Diseases